tract: For health prognostic task, ever-increasing efforts have been focused on machine learning-based methods, which are capable of yielding accurate remaining useful life (RUL) estimation for industrial equipment or components without exploring the degradation mechanism. A prerequisite ensuring the success of these methods depends on a wealth of run-to-failure data, however, run-to-failure data may be insufficient in practice. That is, conducting a substantial amount of destructive experiments not only is high costs, but also may cause catastrophic consequences. Out of this consideration, an enhanced RUL framework focusing on data self-generation is put forward for both non-cyclic and cyclic degradation patterns for the first time. It is designed to enrich data from a data-driven way, generating realistic-like time-series to enhance current RUL methods. First, high-quality data generation is ensured through the proposed convolutional recurrent generative adversarial network (CR-GAN), which adopts a two-channel fusion convolutional recurrent neural network. Next, a hierarchical framework is proposed to combine generated data into current RUL estimation methods. Finally, the efficacy of the proposed method is verified through both non-cyclic and cyclic degradation systems. With the enhanced RUL framework, an aero-engine system following non-cyclic degradation has been tested using three typical RUL models. State-of-art RUL estimation results are achieved by enhancing capsule network with generated time-series. Specifically, estimation errors evaluated by the index score function have been reduced by 21.77%, and 32.67% for the two employed operating conditions, respectively. Besides, the estimation error is reduced to zero for the Lithium-ion battery system, which presents cyclic degradation.