Background: Biomedical AI can generate plausible explanations without reliably verifying whether each statement is supported by patient-specific evidence. We developed a neuro-semantic verification framework that converts radiomic measurements into addressable evidence records and machine-checkable claims. Methods: UPenn-GBM radiomics were aligned with de novo CaPTk extraction from standardized MRI and expert-validated segmentations in an independent multicenter cohort. The shared space comprised 1,728 features from T1, T1GD, T2, and FLAIR MRI across three tumor regions. Reference-defined semantic states were derived from 611 UPenn cases. We evaluated cross-cohort transportability, model-linked provenance, deterministic verification, controlled predictive degradation, and an LLM claim-extraction pilot; MGMT prediction served only as a transport stress test. Results: Median semantic-state agreement was 0.786 (weighted kappa 0.709), ranging from 0.918 for morphologic to 0.252 for intensity features. The external evidence ledger contained 1,655 model-linked records for 331 patients. The verifier achieved 100% exact-set accuracy in a 6,620-claim corruption benchmark. In a 24-case pilot, GPT-5.6 Sol reproduced 72/72 prespecified atomic claims, and the frozen verifier recovered 24/24 expected conditions. During controlled degradation, ROC AUC declined from 0.899 to 0.500 while verification accuracy remained 1.000. External MGMT discrimination was weak (ROC AUC 0.543). Conclusions: Verifiability can be engineered and evaluated independently of predictive performance. LLMs may structure explanations, while final evidence-consistency checking remains deterministic.
https://arxiv.org/abs/2610.08660
Skin cancer is a major global health concern, and early detection and accurate lesion delineation are important for effective diagnosis and treatment planning. Automated skin lesion analysis can assist dermatologists, with lesion segmentation serving as a fundamental step in computer-aided diagnostic systems. Conventional deep learning-based segmentation models typically rely on centralized training, where images and their corresponding segmentation masks are collected on a central server. Such data aggregation raises privacy concerns in medical applications and requires substantial centralized computational resources. To address these limitations, we investigate the feasibility of federated learning for privacy-preserving skin lesion segmentation. The training and validation sets of the ISIC 2018 Skin Lesion Segmentation Challenge dataset are used to simulate a distributed learning environment and develop a federated segmentation model. The resulting model is evaluated on the ISIC 2018 test set and the PH2 dataset to assess its performance and generalizability. Experimental results demonstrate that the federated model achieves performance comparable to centralized training while consistently improving upon the locally trained models. These findings demonstrate the potential of federated learning for collaborative skin lesion segmentation without requiring centralized aggregation of medical images.
https://arxiv.org/abs/2610.08574
Handcrafted preprocessing is widely employed in automated dermoscopic analysis to suppress imaging artifacts and enhance lesion visibility. Nevertheless, its actual contribution to modern real-time models remains unclear, particularly when evaluation protocols do not adequately control correlations among images of the same lesion. This study presents a leakage-controlled, lesion-disjoint evaluation of dermoscopic preprocessing and augmentation for joint multi-class lesion classification and instance segmentation using a fixed nano-scale YOLO26 segmentation model (YOLO26n-seg). From HAM10000 (10,015 images), quality control yields 10,013 valid image-mask pairs from 7,468 unique lesions, partitioned into mutually exclusive sets by lesion identity. With the architecture, resolution, training budget, and evaluation protocol held fixed, we compare minimally processed images plus online augmentation against offline class balancing, DullRazor-CLAHE preprocessing, and raw-processed hybrid views, over three random seeds. On the lesion-disjoint test set, the raw baseline achieves a mask mAP$_{50:95}$ of $0.5636 \pm 0.0234$, a Dice score of $0.9356 \pm 0.0024$, and a macro-F1 score of $0.6917 \pm 0.0202$. Offline augmentation does not improve the mean performance, while the combined and hybrid strategies reduce both class-aware segmentation and classification accuracy. At only 2.69 million parameters, the model runs at approximately 50 frames per second. Under a leakage-controlled, lesion-disjoint protocol with all non-input factors held fixed, minimally processed dermoscopic images combined with standard online augmentation deliver a better accuracy-efficiency trade-off than increasingly complex deterministic preprocessing, which yields no consistent joint benefit across three seeds on HAM10000.
https://arxiv.org/abs/2610.08570
Polarization imaging provides physical cues beyond intensity imaging but typically requires specialized hardware. Recent methods infer polarization from RGB-like inputs, yet predict only normalized Stokes components or relative descriptors, from which the radiometric scale needed for full Stokes reconstruction has been divided out. We introduce PolarScale, a benchmark that makes this scale an explicit prediction and evaluation target. Built on existing trichromatic full-Stokes measurements, PolarScale takes the per-scene normalized total-intensity image $s_0$ (a scene-referred linear image, not a consumer sRGB photograph) and asks models to predict normalized Stokes components, AoLP/DoLP/DoCP, and a per-scene scale. Because the scale is divided out of the input, it is not physically identifiable; PolarScale therefore evaluates dataset-conditioned semantic scale estimation against a constant-scale control, together with angular, self-consistency, and physical-bound metrics. Across seven restoration-based and generative backbones and three prediction strategies, the strongest restoration models estimate the scale with 3.6-4.3% mean relative error versus 5.7% for the constant control and violate physical bounds on fewer than 0.25% of pixels, whereas two generative baselines collapse to a near-zero scale; explicit descriptor supervision improves descriptor accuracy (23.66 vs. 18.88 dB PSNR for MAE). Predicted full-Stokes representations improve diffuse/specular separation, material segmentation, and glare classification, although in diffuse/specular separation the learned scale performs only on par with the constant control.
https://arxiv.org/abs/2610.08346
Early osteoarthritis detection through quantitative MRI (qMRI) requires accurate cartilage and meniscus segmentation, traditionally necessitating time-consuming, costly 3D high-resolution Double Echo Steady-State (DESS) MRI scans. This study developed a multi-task conditional generative adversarial network (MT-cGAN) to simultaneously synthesize DESS-like images and segment tissues directly from qMRI echo images. This retrospective study evaluated 508 knee MRI volumes from 361 subjects (mean age: $40.4 \pm 12.2$ years; 179 female) across three cohorts. Ground truth segmentation masks were generated from DESS images using a pretrained model with manual correction, and $T_{1\rho}$ and $T_2$ maps were computed from magnetization-prepared angle-modulated partitioned $k$-space spoiled gradient echo snapshots (MAPSS) echo images. MT-cGAN was trained to jointly synthesize DESS-like images and segment cartilage and meniscus directly from echo images. Model performance was evaluated using Dice score for segmentation accuracy and coefficient of variation (CV) for $T_{1\rho}$ and $T_2$ quantification. MT-cGAN achieved the highest segmentation performance, mean Dice score 0.84 (range: 0.80--0.86) across all cartilage and meniscus compartments and significantly outperformed the state-of-the-art conditional GAN model with transfer learning (mean Dice, 0.82; $p < 0.001$, Wilcoxon signed-rank test). For relaxometry quantification, MT-cGAN demonstrated the highest consistency with the reference DESS protocol, yielding the lowest CV ($T_{1\rho}$: 1.84%, $T_2$: 1.81%). The proposed MT-cGAN accurately segmented cartilage and menisci while providing reliable $T_{1\rho}$ and $T_2$ quantification directly from echo images. By eliminating the need for separate morphological DESS scans, this workflow reduces required scan times to facilitate the clinical translation of qMRI.
https://arxiv.org/abs/2610.06602
Conditional neural fields represent signals continuously, but their effectiveness depends on how the conditional latent representations are inferred from observed data. In meta-learning, this encoding occurs through gradient updates induced by the decoder, tying representation learning directly to decoder design. We formalize this connection by interpreting latent optimization as an optimization encoder, unifying the roles of second-order differentiation, latent parameterization, and task supervision. This concept enables second-order meta-learning for end-to-end training of the encoding procedure alongside the decoder, and clarifies which learning pathway first-order approximations discard. Guided by this view, we introduce Attentive Latent Fields (MetaLF), an equivariant transformer-based neural field that contextualizes a latent pointcloud through self-attention. These interactions shape both field predictions and the updates that construct their representation, allowing local observations to inform coherent non-local structure. Disentangling the inner encoding objective from outer task supervision unifies reconstruction, classification, and segmentation within an end-to-end meta-learning framework, using reconstruction-only latent adaptation at test time. Controlled experiments on polynomial fields link latent coordination to lower effective rank and stronger alignment with the underlying function space. Across image and 3D shape reconstruction, MetaLF improves fidelity within three to five gradient updates, while supporting semantic prediction across images, shapes, and volumes. Together, these findings position the optimization encoder perspective as a unified basis for designing neural fields around how representations are constructed, coordinated, and used.
https://arxiv.org/abs/2610.08075
This study analyzes the predictive power of LM-derived, token-level surprisal on Mandarin Chinese reading times. We first propose the Shortest Matching Sequence (SMS), an alignment scheme that maps between the word segmentation assumed by eye-tracking corpora and the LMs' subword tokenization, as the two tokenizations often disagree in the context of Mandarin Chinese. Then, using a suite of Chinese-Pythia models (14M-1.4B) trained on scratch with 30B tokens, we examine how well surprisal predicts first fixation duration, gaze duration, and total reading time in three paragraph-level eye-tracking corpora of Mandarin Chinese (GECO-CN, HKP, and MECO). Contrary to previous null findings, our results show that surprisal is predictive of Chinese reading times. However, whether predictive power scales with model size and the amount of training is corpus-specific: bigger models predict better in GECO-CN, whereas inverse scaling emerges in HKP and, at the largest sizes, in MECO. Subsequently, we tested one possible explanation for the inverse scaling in HKP and found that checkpoints whose surprisal remains closer to $n$-gram statistics are better predictors of reading. All in all, the predictive power of surprisal on Chinese reading time measurements is corpus-specific, which cautions against drawing scaling conclusions from a single corpus.
https://arxiv.org/abs/2610.04898
Instance-level roof-to-footprint offset (RFO) prediction is central to extracting building footprints from off-nadir imagery. Query-based pipelines commonly use high-dimensional instance tokens to predict signed two-dimensional RFOs. We investigate whether RFO prediction can instead use a compact offset token. Under local pinhole projection and vertical-extrusion assumptions, the idealized RFO map admits a five-parameter sufficient descriptor comprising intrinsic shape, composite amplitude, and relative geometry. This factorization provides a structural prior for a five-dimensional offset token, whose channels learn task-relevant latent representations through end-to-end training. Based on this design, we propose LoDEOT, which retains high-dimensional instance tokens for detection and segmentation but maps instance-token, concentration-gated roof, and box-mask evidence to a five-dimensional offset token followed by an independent two-dimensional readout. Known denoising-query target indices further align each supervised decoder-layer estimate with the same clean instance RFO, organizing successive predictions as target-aligned recovery under perturbed query conditions. Experiments on five real-world building datasets demonstrate the effectiveness of LoDEOT for building footprint extraction. Experiments on real-world building datasets demonstrate that a five-dimensional offset token can support accurate RFO prediction. On BONAI, LoDEOT achieves the best roof-detection bAP and bAP50 and leads all five offset-corrected footprint metrics among the evaluated end-to-end methods, with FAP50 of 54.58 and mEPE of 5.23 pixels. Its FAP50 exceeds those of the evaluated end-to-end baselines by 7.56-16.85 percentage points.
https://arxiv.org/abs/2610.05899
Bird monitoring in natural environments is challenging due to the small size of some species of birds relative to the scene, background clutter, variability in illumination, and the observers' viewpoint. Progress is further limited by the scarcity of large-scale, realistic datasets, which are essential for understanding behavioral patterns. To address this gap, we introduce a new benchmark dataset for the detection and segmentation of Western bluebirds (Sialia Mexicana), comprising over 6,000 labeled images from 41 recording sessions. The dataset features high-resolution (4K) in-the-wild images in which birds occupy only a small fraction of the image. We evaluated supervised detectors, open-vocabulary models under zero-shot and fine-tuned settings, and segmentation approaches. Supervised detectors remain the most reliable overall, with Faster R-CNN achieving the highest detection mAP and RT-DETR offering the best precision-recall trade-off. Open-vocabulary models perform poorly in zero-shot settings; however, fine-tuning substantially improves their performance, with YOLO-World becoming competitive with supervised methods and achieving the highest precision, F1-score, and mAP@0.5. For segmentation, supervised methods significantly outperform Grounded-SAM and SAM 3: Mask R-CNN achieves the highest mask mAP, while YOLOv8-Seg provides the best precision and fastest inference. A diagnostic analysis further shows that failures are not explained by object size alone, but by a combination of apparent scale, brightness, contrast, clutter, blur, crowding, and recording-session variation. Overall, our findings highlight the difficulty of zero-shot bird detection in cluttered ecological scenes and underscore the importance of domain adaptation in small-object settings.
https://arxiv.org/abs/2610.07802
This paper revisits frame-wise saliency for audio moment retrieval (AMR). We show that the frame-wise saliency sequence, conventionally used only as an auxiliary output in DETR-based AMR models, can itself serve as an effective source of moment predictions. We convert the saliency sequence into ranked moments using a simple SED-inspired segmentation rule with no learned parameters, enabling moment retrieval directly from frame-wise temporal information. On the CASTELLA dataset, saliency-based prediction consistently outperforms decoder-based prediction from the same model across all 18 runs of QD-DETR and CG-DETR. For QD-DETR, simply replacing the inference output improves R1@0.7 from 21.0 to 36.1. The advantage remains 7-15 points when the two outputs are evaluated at their independently selected best epochs. The same tendency extends to TaskWeave and UVCOM, whereas TR-DETR shows the opposite behavior, suggesting that how saliency construction may matter. The performance gap is especially pronounced for short moments: for queries whose annotated moments average at most 2 s, R1@0.7 improves from 6.3 to 27.8 with QD-DETR. Decoder supervision nevertheless benefits saliency-based prediction, indicating that its role during training differs from the utility of its inference output.
https://arxiv.org/abs/2610.05737
Accurate nuclei instance segmentation is essential for quantitative renal pathology, yet general-purpose models often struggle with low contrast, dense nuclei, complex morphology, and strong background staining. In this work, we extended a human-in-the-loop framework by combining 5,901 foundation-model-generated pseudo-labels from well-segmented cases (Easy), 860 newly expert-annotated unresolved challenging cases (Medium), and 198 expert-annotated consensus failure cases (Hard). These annotations, spanning different levels of segmentation difficulty, enabled the systematic evaluation of seven single-source and mixed-source fine-tuning strategies across nine cell segmentation model configurations. Fine-tuning improved all models, with Medium data included in seven of the nine best-performing strategies. LSP-DETR achieved the highest F1 score of 0.8725 with Hard-only fine-tuning, while StarDist showed the largest improvement, increasing from 0.7380 to 0.8332 with Medium-only fine-tuning. These findings show that annotations spanning multiple difficulty levels support effective model adaptation, although the optimal annotation composition remains model dependent.
https://arxiv.org/abs/2610.07711
Reconstructing cortical WM and pial surfaces from structural magnetic resonance imaging (MRI) is a prerequisite for surface-based neuroanatomical analysis, yet remains challenging because the cortex is thin and tightly folded. Reconstruction methods can produce geometric artifacts such as mesh self-intersections and collisions between cortical surfaces, and although recent deep learning methods have reduced reconstruction time from hours to minutes, these artifacts persist. We propose SimCortex v2, a deep learning framework for simultaneous reconstruction of the left and right WM and pial surfaces from T1-weighted MRI. SimCortex v2 estimates topologically correct initial surfaces from a volumetric segmentation and refines all four jointly using multi-scale stationary velocity fields predicted by a ribbon-conditioned, U-Net-like network. We evaluated SimCortex v2 on 560 cases from 14 cohorts, thirteen of them unseen during training, spanning ages 6-89, healthy and clinical populations, and scanners from three vendors. SimCortex v2 matched the surface-distance accuracy of the strongest baseline (average symmetric surface distance 0.253 mm) while showing no detected inter-surface collision in 92.14% of cases and the lowest self-intersection fraction (0.044%) among learning-based methods, whereas every baseline produced at least one collision in every case. Source code, configuration files, pretrained weights, preprocessed data, and the exact evaluation splits are publicly released.
https://arxiv.org/abs/2610.07378
Audio benchmarks are built around short, pre-segmented clips, limiting model design to brief inputs or fixed vocabularies. To close this gap, we introduce Logbook, a benchmark for hour-scale audio understanding, with recordings ranging from ten minutes to six days. Given a continuous audio recording and an event label vocabulary, a system must predict a gap-free segmentation with an event label and a description per segment. We compare 52 systems, end-to-end and cascaded, and ablate fine-tuning, context length, and reasoning budget. We find the task tractable, though the best systems remain below the human reference. Also, over-segmentation is pervasive, and fine-tuning partially mitigates it. Finally, end-to-end are often better than cascaded systems, but degrades with longer context.
https://arxiv.org/abs/2610.07338
Deep-water biological observation is essential for understanding marine organisms and their interactions with the environment. However, conventional optical and acoustic approaches can introduce stimuli that alter animal behavior and bias biological observations. This paper proposes a fluorescence-enhanced whisker array sensing system that pinpoints underwater hydrodynamic sources through local optical readout rather than direct source imaging. Five spatially oriented whiskers, fabricated with nitinol cores and fluorescent urethane shells, are integrated with ultraviolet excitation and a monocular camera. Image enhancement and segmentation are applied to track the whisker deformation. A lightweight convolutional neural network captures temporal and cross-whisker features from 2 s sequences to estimate source localization. Pool experiments achieve a mean spatial localization error of 88 mm, with 73.5 mm in radius and $2.5^\circ$ in angle, across a test region of 600 mm with $\pm30^\circ$. Real-time localization of a moving thruster demonstrates the capability of the proposed method in dynamic scenarios, highlighting its potential for integration into underwater robots for hydrodynamic source detection, localization, and tracking in low-light environments.
https://arxiv.org/abs/2610.07275
RGB-D semantic segmentation has made notable progress by fusing RGB and Depth, yet mainstream models still learn features almost exclusively from pixel-level supervision, lacking direct high-level semantic constraints. This raises a central question-can external knowledge such as language priors inject stronger semantic discriminability into mainstream RGB-D segmentation models. We present DTFormer, a novel tri-modal (RGB-D-Text) semantic segmentation framework. At its core is Text-guided Semantic Alignment Module (TSAM) that first encodes textual cues into a set of semantic prototypes and then explicitly aligns multi-modal RGB-D features with these prototypes at multiple encoder and decoder layers. This design imposes strong semantic regularization on representation learning, guiding the network toward more discriminative features. Extensive experiments on multiple benchmarks show that DTFormer delivers consistent gains while remaining simple and efficient. Our results demonstrate that explicit semantic alignment offers an effective and practical route to improving RGB-D semantic segmentation. The code will be released upon acceptance.
https://arxiv.org/abs/2610.07014
Diffusion models learn semantic representations while generating images. In the Decoupled Diffusion Transformer (DDT), a condition encoder provides features that guide a velocity decoder in denoising. To enable effective denoising at all noise levels, these features must capture both high-level abstract structures and low-level details. However, skip/residual connections in the encoder allow shallow features to bypass successive transformations, which may limit progressive abstraction, or at least make it difficult to disentangle different levels of abstraction. We propose DDT-RFE, which removes the residual connections around the Self-Attention and MLP operations in each encoder block while maintaining stable training. To retain the information that abstraction discards but that the decoder still needs, we fuse the input patch embedding with intermediate and final encoder features to form the encoder output. The decoder thus has access to information from multiple encoder depths, while each encoder block is able to learn more abstract representations. DDT-RFE achieves overall improvements over DDT across visual understanding tasks, including image classification, semantic segmentation, object discovery, and semantic correspondence, while using fewer encoder blocks. It also achieves a lower FID for image generation on ImageNet.
https://arxiv.org/abs/2610.07002
Medical image segmentation remains fragmented along two axes: segmentation paradigms and data dimensionality. Existing methods are typically developed separately for semantic, in-context, and interactive segmentation, and are further specialized to either native 2D images or 3D volumetric data. In clinical practice, however, segmentation workflows take many forms: a case may be initialized by semantic prediction, reference-guided segmentation, or user interaction. Regardless of how it begins, fine-grained refinement is naturally performed on 2D views; for volumetric scans, such 2D edits must propagate coherently to the rest of the volume. We present UniPro, a unified model that bridges segmentation paradigms and data dimensionality, using propagation to extend 2D segmentation to 3D volumes. Our key insight is that volumetric propagation and in-context segmentation share the same reference-conditioned prediction mechanism, differing only in whether the reference image-mask pairs come from other cases or from previously segmented neighboring slices. Building on this view, UniPro supports semantic, in-context, interactive, and propagation-based segmentation within a single slice-based framework, using class priors, reference exemplars, user clicks, and neighboring-slice predictions as mode-specific conditioning inputs. To improve propagation reliability, UniPro further incorporates bidirectional and 3D supervision to regularize slice-wise propagation beyond per-slice losses. Extensive experiments across diverse modalities and anatomies show that UniPro achieves strong performance across all segmentation settings, enabling annotation-efficient 3D segmentation from sparse 2D initialization and reducing slice-by-slice correction effort.
https://arxiv.org/abs/2610.06938
Spatial semantic segmentation of sound scenes (S5) involves the detection and extraction of target sound events in audio files. However, in typical detection-extraction pipelines, errors in the detection module propagate to the extraction module, degrading overall performance. In this work, we develop a multichannel detection-extraction model and evaluate inference-time algorithms to improve the class detection and target sound extraction in a multi-stage setup. We evaluate two fitness functions: binary cross entropy and mixture consistency; two relabeling strategies: naive and conditional confusion matrix relabeling; and three source estimate evaluation models: a multi-label classifier, a fine-tuned single-source classifier, and an off-the-shelf audio judge. We thoroughly evaluate the impact of these design choices on the DCASE 2025 Task 4 dataset, and validate entropy-based gating of inference-time updates on the held-out evaluation set, laying the groundwork for inference-time updates of S5 systems in real-world scenarios.
https://arxiv.org/abs/2610.03602
World action models (WAMs) have advanced robot control by predicting how observations and actions evolve over time. Despite this progress, RGB and action based future prediction does not explicitly address the spatial understanding needed for robot manipulation. Existing efforts often add a limited set of spatial prediction tasks through specialized heads or branches, leaving both the range of spatial supervision and the model architecture fragmented. We introduce XGenAct, a world action model that represents RGB observations, robot actions, metric depth, surface normals, and functional role segmentation as RGB videos through deterministic codecs. By sampling perception and action tasks during training, XGenAct uses one video diffusion transformer and one objective to learn temporal prediction across these spaces without modality specific learned heads. On held out RLBench tasks, structured perception training improves average closed loop success over RGB only training, and XGenAct achieves 52% success in the five task external comparison, versus 26% for the strongest evaluated baselines. It also predicts future depth and segmentation more accurately than the evaluated pipelines that generate RGB first and then apply a frozen perception expert.
https://arxiv.org/abs/2610.03516
Federated learning (FL) enables collaborative training of medical image segmentation models without sharing raw patient data, yet existing approaches assume a homogeneous compute budget across institutions, limiting participation of low-resource sites. We propose Fed-ADApt, a depth-adaptive federated framework for UNet-based segmentation that jointly addresses low-compute training and inference. Fed-ADApt integrates multi-depth supervision with hierarchical depth-wise aggregation, allowing each site to train according to its local compute budget while contributing to a global model that supports dynamic depth selection at deployment. We evaluated Fed-ADApt on multi-site 2D retinal fundus disc segmentation and 3D brain tumor segmentation. Across both tasks, federated collaboration substantially improves robustness under domain shift. Fed-ADApt matched the full-resource FedAvg performance in 3D and achieved competitive 2D performance with a 4.7% average Dice reduction, while reducing average inference cost by 19.5% in 3D and 34.5% in 2D and substantially reducing training cost by 98% at the most constrained sites. Importantly, Fed-ADApt enables low-resource institutions that cannot train full-capacity models to participate in federations while maintaining competitive global performance under a favorable accuracy to efficiency trade-off. By considering training and inference compute budgets, Fed-ADApt provides a practical and equitable solution for federated medical image segmentation across heterogeneous clinical and edge-enabled imaging environments.
https://arxiv.org/abs/2610.03474