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An Effective GCN-based Hierarchical Multi-label classification for Protein Function Prediction

2021-12-06 06:45:49
Kyudam Choi, Yurim Lee, Cheongwon Kim, Minsung Yoon
arXiv_AI
             
Abstract

We propose an effective method to improve Protein Function Prediction (PFP) utilizing hierarchical features of Gene Ontology (GO) terms. Our method consists of a language model for encoding the protein sequence and a Graph Convolutional Network (GCN) for representing GO terms. To reflect the hierarchical structure of GO to GCN, we employ node(GO term)-wise representations containing the whole hierarchical information. Our algorithm shows effectiveness in a large-scale graph by expanding the GO graph compared to previous models. Experimental results show that our method outperformed state-of-the-art PFP approaches.

Abstract (translated)

URL

https://arxiv.org/abs/2112.02810

PDF

https://arxiv.org/pdf/2112.02810.pdf

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