Abstract
In this paper, we investigated whether we can 1) detect participants with ataxia-specific gait characteristics (risk-prediction), and 2) assess severity of ataxia from gait (severity-assessment). We collected 155 videos from 89 participants, 24 controls and 65 diagnosed with (or are pre-manifest) spinocerebellar ataxias (SCAs), performing the gait task of the Scale for the Assessment and Rating of Ataxia (SARA) from 11 medical sites located in 8 different states in the United States. We developed a method to separate the participants from their surroundings and constructed several features to capture gait characteristics like step width, step length, swing, stability, speed, etc. Our risk-prediction model achieves 83.06% accuracy and an 80.23% F1 score. Similarly, our severity-assessment model achieves a mean absolute error (MAE) score of 0.6225 and a Pearson's correlation coefficient score of 0.7268. Our models still performed competitively when evaluated on data from sites not used during training. Furthermore, through feature importance analysis, we found that our models associate wider steps, decreased walking speed, and increased instability with greater ataxia severity, which is consistent with previously established clinical knowledge. Our models create possibilities for remote ataxia assessment in non-clinical settings in the future, which could significantly improve accessibility of ataxia care. Furthermore, our underlying dataset was assembled from a geographically diverse cohort, highlighting its potential to further increase equity. The code used in this study is open to the public, and the anonymized body pose landmark dataset could be released upon approval from our Institutional Review Board (IRB).
Abstract (translated)
URL
https://arxiv.org/abs/2203.08215
