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Attention-based Multiple Instance Learning for Survival Prediction on Lung Cancer Tissue Microarrays

2022-12-15 11:07:23
Jonas Ammeling, Lars-Henning Schmidt, Jonathan Ganz, Tanja Niedermair, Christoph Brochhausen-Delius, Christian Schulz, Katharina Breininger, Marc Aubreville
arXiv_CV
     
Abstract

Attention-based multiple instance learning (AMIL) algorithms have proven to be successful in utilizing gigapixel whole-slide images (WSIs) for a variety of different computational pathology tasks such as outcome prediction and cancer subtyping problems. We extended an AMIL approach to the task of survival prediction by utilizing the classical Cox partial likelihood as a loss function, converting the AMIL model into a nonlinear proportional hazards model. We applied the model to tissue microarray (TMA) slides of 330 lung cancer patients. The results show that AMIL approaches can handle very small amounts of tissue from a TMA and reach similar C-index performance compared to established survival prediction methods trained with highly discriminative clinical factors such as age, cancer grade, and cancer stage

Abstract (translated)

URL

https://arxiv.org/abs/2212.07724

PDF

https://arxiv.org/pdf/2212.07724.pdf

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