Classification
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Supervision versus Demonstration-Based In-Context Learning for Multiword Expression Classification
2026-06-05 17:34:07Sercan Karaka\c{s}, Yusuf \c{S}im\c{s}ekAbstract
Turkish idiomatic light verb constructions (LVCs) are challenging for multiword expression processing because they often share the same surface form as fully literal verb-object combinations while functioning as a single, partially idiomatic predicate. We frame Turkish LVC detection as a binary classification task (literal meaning vs. idiomatic meaning) and evaluate on a manually created controlled set (N=147) with matched negatives: out-of-domain random sentences and in-domain literal controls (NLVC), alongside LVC positives. We compare a supervised Turkish encoder baseline (BERTurk with a classifier head) to three instruction-tuned LLMs from different families under zero-shot, one-shot, and few-shot prompting, and analyze how demonstrations shift error profiles. In zero-shot, LLMs perform well on negatives but show very low LVC recall. One-shot prompting sharply improves LVC detection but can induce strong, model-specific biases, leading models to overpredict or underpredict LVCs. A richer few-shot prompt improves calibration and yields robust overall performance for GPT-OSS-20B and Qwen 2.5-14B. Overall, the results highlight substantial prompt sensitivity in Turkish metalinguistic classification: the supervised baseline remains competitive, while prompted LLMs can match or exceed it on LVCs with carefully constructed demonstrations.
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URL
https://arxiv.org/abs/2606.07479
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Graph Neural Network leveraging Higher-order Class Label Connectivity for Heterophilous Graphs
2026-06-05 17:28:19Takuto Takahashi, Itsuki Nakayama, Takahiro Mitani, Ryosuke Kikuchi, Yuya Sasaki, Makoto OnizukaAbstract
Node classification in graph neural networks (GNNs) has been widely applied in various fields of graph analysis. GNNs achieve high-accuracy node classification in homophilous graphs, where nodes with the same class label tend to be connected. However, their performance remains limited in heterophilous graphs, where nodes with different class labels are more likely to be connected. In particular, current GNNs derived from graph convolutional networks cannot capture higher-order class label connectivity, which is frequently observed in real-world heterophilous graphs. To address this issue, we propose a novel classifier, Label Context Classifier (LCC), designed to capture higher-order class label connectivity in directed graphs. LCC estimates the class label of a target node by leveraging label context embeddings that are generated through four distinct types of walks. In addition, our approach allows the integration of LCC and any GNN by adaptively learning their importance. Experimental results demonstrate that GNNs integrated with LCC outperform SOTA methods and the label context embeddings improve the node classification performance in heterophilous directed graphs.
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URL
https://arxiv.org/abs/2606.07475
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Mind the Gap: Disentangling Performance Bottlenecks in Video Instance Segmentation
2026-06-05 15:32:48Danial Hamdi, Fardin Ayar, Mahdi JavanmardiAbstract
In Video Instance Segmentation (VIS), classification, segmentation, and tracking objectives are jointly evaluated, but their individual contributions to performance loss remain opaque. We introduce a diagnostic framework that formulates identity and class assignment as an Integer Linear Program (ILP), yielding a model-agnostic oracle that hierarchically isolates each error source. Applied to seven VIS methods spanning online and offline paradigms across YouTube-VIS 2019/2021 and a diagnostic subset of OVIS, our analysis reveals a consistent picture. Tracking instability is a critical bottleneck for online methods, with gaps exceeding 20 AP under heavy occlusion, and grows sharply with video length and instance density. While semantic classification contributes meaningfully on standard benchmarks, its impact becomes negligible where tracking fails most. Although stronger backbones substantially lift default scores, they leave AP tracking gaps largely intact, confirming that temporal fragility is algorithmic rather than purely representational. To complement the oracle, we introduce TrackLens, a visual tool that translates gap magnitude into observable, query-level failure modes. Together, these tools provide a systematic foundation for targeting VIS's core challenge: robust long-term temporal association.
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https://arxiv.org/abs/2606.07394
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Impact of Synthetic Lesional MR Images in Automated Focal Cortical Dysplasia Detection in Low-Data Scenarios
2026-06-05 15:21:22Prabhjot Kaur, Hakim Ouaalam, Sedat Kandemirli, Sanjay P. Prabhu, Simon K. WarfieldAbstract
Background and Purpose: Automated detection of focal cortical dysplasia (FCD) requires large volumes of voxelwise lesion-delineated MRI data, which are difficult to acquire. This study aims to generate synthetic MRI data exhibiting FCD, assess their realism, and evaluate their impact on automated FCD detection, particularly in reducing the need for manual annotations. Methods: T1-weighted (T1w) and T2-weighted Fluid-Attenuated Inversion Recovery (FLAIR) MRI scans from 131 FCD patients and 90 healthy controls from multiple (3) sites were retrospectively studied. Synthetic MRIs were generated by conditioning a generative network on binary FCD masks. Two neuroradiologists identified real images from a random set of 14 real and 14 synthetic scans. Three nnU-Net models were trained to detect FCD using: (i) real-only (35 FCD / 35 controls), (ii) real (35 FCD / 35 controls) plus synthetic augmentation, and (iii) expanded real data (70 FCD / 70 controls). Results: Experts showed limited ability to distinguish real from synthetic images, with classification accuracy of 60% for T1w and 70% for FLAIR (inter-rater agreement kappa = 0.86). Augmenting automated FCD detection with synthetic data increased sensitivity by 8.14% (p = 0.12) and improved model confidence at true lesion sites (0.83 +/- 0.11 to 0.89 +/- 0.12; p = 0.02). The expanded real-data model further improved sensitivity to 73.8% (p < 0.001) and confidence to 0.90 +/- 0.14 (p = 0.01). Conclusion: Conditional generative networks can generate realistic synthetic FCD-MRIs, reducing labeled data needs by approximately 20% while maintaining equivalent sensitivity. Equivalent amounts of real data, when available, remain more effective than synthetic augmentation.
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URL
https://arxiv.org/abs/2606.07381
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Mitosis Detection in the Wild: Multi-Tumor and Context-Aware Generalization in the MIDOG 2025 Challenge
2026-06-05 15:11:08Marc Aubreville, Jonas Ammeling, Sweta Banerjee, Viktoria Weiss, Taryn A. Donovan, Robert Klopfleisch, Jiaqi Lv, Shan E Ahmed Raza, Rapha\"el Bourgade, Thomas Walter, Yasemin Topuz, Song\"ul Varl{\i}, Charles-Antoine Collins-Fekete, Zhuoyan Shen, Navya Sri Kelam, Nitin Singhal, Christian Marzahl, Brian Napora, Tengyou Xu, Hongyan Gu, Mario Vento, Gennaro Percannella, Norbert Ropiak, Izabela Wasiak, Jie Xiao, Shaojun Liu, Seungho Choe, April Khademi, Vidushi Walia, Sujatha Kotte, Andrew Broad, Alex Wright, Guillaume Balezo, Esha Sadia Nasir, Mostafa Jahanifar, Yosuke Yamagishi, Shouhei Hanaoka, Mattia Sarno, Francesco Tortorella, Biwen Meng, Jingxin Liu, Sara Krauss, Daniel Hieber, Lavish Ramchandani, Dev Kumar Das, Mieko Ochi, Yuan Bae, Piotr Giedziun, Mateusz Maniewski, Vangala Govindakrishnan Saipradeep, Naveen Sivadasan, Leire Benito-Del-Valle, Adrian Galdran, Kaustubh Atey, Sameer Anand Jha, Adinath Dukre, Imran Razzak, Maxime W. Lafarge, Viktor H. Koelzer, Nils Porsche, Nikolas Stathonikos, Mitko Veta, Dominik Hirling, Zsanett Zs\'ofia Iv\'an, Peter Horvath, Katharina Breininger, Christof A. BertramAbstract
Automated mitosis detection is a well-established task in computational pathology. While previous benchmarks focused on scanner-induced domain shift, clinical "real-world" application requires models to be robust across the vast variance to be expected in the histological landscape. The MItosis DOmain Generalization (MIDOG) 2025 challenge was designed to evaluate algorithmic performance across unprecedented biological and contextual diversity. We curated a test dataset of 365 cases, encompassing 12 distinct human, canine and feline tumor types, digitized across multiple scanning platforms. Moving beyond hand-selected hotspots, the challenge required detection also in random tissue areas (representative of the whole slide detection situation) and challenging areas (areas rich in hard negatives). In the second track, we introduced the classification of atypical mitotic figures (AMFs). There were 18 teams submitting to the detection track, with F1 scores ranging up to 0.740. In the AMF detection track, we had 21 submissions with balanced accuracy values up to 0.908. Our analysis reveals that while most models perform reliably in traditional hotspots, significant performance degradation occurs in challenging ROIs, where false positive rates tripled. Furthermore, performance varied significantly across the 12 tumor types, highlighting "blind spots" in current state-of-the-art architectures when encountering rare or highly pleomorphic malignancies. Moreover, we evaluated the effectiveness of ensembling and found a mean increases of 1.5 and 1.3 percentage points in F1 score and balanced accuracy, respectively. In contrast, TTA showed no relevant improvement. MIDOG 2025 demonstrates that "in the wild" mitosis detection remains a significant hurdle. The transition from hotspot-only evaluation to a multi-contextual framework provides a more realistic proxy for clinical reliability.
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URL
https://arxiv.org/abs/2606.07368
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SleepExplain: Explainable Non-Rapid Eye Movement and Rapid Eye Movement Sleep Stage Classification from EEG Signal
2026-06-05 15:00:33Rafsan Jany, Md. Hamjajul Ashmafee, Iqram Hussain, Md Azam HossainAbstract
Classification of sleep stages is one of the most important diagnostic approaches for a variety of sleep-related disorders. Electroencephalography (EEG) is regarded as a powerful tool for examining the association between neurological effects and sleep phases since it correctly identifies sleep-related neurological alterations. During Non-Rapid Eye Movement (NREM) and Rapid Eye Movement (REM) sleep phases, a number of nerve and bodily functions are affected and therefore hold an important role both in their functionalities. This work aims to classify NREM and REM sleep stages from sleep EEG data and present a noble SleepExplain model, an explainable NREM and REM sleep stage classification to explain its predictions. In this work, sleep stages were classified using Random Forest, XGBoost, and Gradient Boosting ensemble classification models. Overall, we obtained an accuracy of 92.54% (Random Forest), 94.25% (Gradient Boosting), and 94.30% (XGBoost). For explainable classification model, we utilized a game theoretic approach, SHAP (SHapley Addictive exPlanations) to offer a convincing explanation for the prediction.
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URL
https://arxiv.org/abs/2606.07351
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LLM-Guided Evolution for Medical Decision Pipelines
2026-06-05 14:53:16Ivan Sviridov, Artem Oskin, Ivan Panin, Iaroslav Bespalov, Dmitry Dylov, Ivan Oseledets, Aleksandr NesterovAbstract
Adapting large language models (LLMs) to clinical workflows often requires costly fine-tuning or manual prompt and pipeline engineering. We study LLM-guided MAP-Elites evolution as an inference-time alternative for discovering medical decision strategies and provide an implementation repository at this https URL. We formulate urgency triage, interactive consultation, and medical image classification as evolutionary searches over executable artifacts optimized by task-specific fitness functions. Across all three settings, evolution improves over manually designed baselines under practical constraints. In triage, evolved programs increase Semigran accuracy from $77.3\%$ to $87.1\%$ and emergency recall from $0.60$ to $0.97$, while improving safety-weighted held-out MIMIC-ESI performance. In interactive consultation, evolved policies improve the accuracy--cost frontier across Llama-3, Qwen-3.5, and Gemma-4 and transfer to held-out iCRAFTMD. In PneumoniaMNIST, prompt-only evolution improves frozen MedGemma VLMs while preserving strict JSON outputs. Qualitative analysis shows that the gains come from interpretable program-level mechanisms, calibrated triage boundaries, targeted evidence acquisition, selective commitment, and finding-oriented visual decision rules, rather than superficial prompt rewording alone.
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URL
https://arxiv.org/abs/2606.07342
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How Far Can Chord-Symbol Time-Series Adaptation Carry Genre Identity? Capabilities and Boundaries in Multi-Genre Chord-Symbol Modeling
2026-06-05 14:49:24Jinju LeeAbstract
Harmony is a compact symbolic layer where mathematical pitch relations, acoustic consonance, and musical convention meet. This report treats chord-symbol sequences not as a complete representation of music, but as an interpretable, controllable time series for genre-local harmonic modeling. Starting from a frozen pop-jazz Music Transformer checkpoint, I evaluate how far small adaptation interfaces can extend the model to eleven target genres: blues, bossa nova, Bach chorales, country, electronic, folk, funk, gospel, hip-hop, R&B/soul, and rock. The main evaluation compares LoRA, IA3, BitFit, prefix tuning, and full fine-tuning over 11 genres and 3 seeds, a complete 165-cell grid. All five methods improve over the frozen base on held-out chord prediction, with macro gains from +2.89 to +3.61 points; LoRA and IA3 score highest, but Wilcoxon tests with Holm and Benjamini-Hochberg correction do not support a decisive winner. A matched-data-size control sharpens this: when genres are sub-sampled to a common corpus size, IA3 stays on top but LoRA's full-data edge disappears and it falls to last, indicating the small gaps are partly data-driven. A control-token baseline is also strong, and wrong-genre adapters often beat the frozen base, suggesting much of the effect comes from lightweight conditioning over a reusable harmonic base rather than one particular adapter family. Additional diagnostics (rank sweeps, wrong-genre rotation, a base-checkpoint ablation, chord-only genre classification, generated-output statistics, real-song evaluation, and duplicate analysis) support a bounded conclusion: chord-symbol adaptation reliably improves genre-local harmonic prediction, but chord symbols alone do not carry complete genre identity. The report therefore avoids claims about perceived genre authenticity or full musical quality, which require controlled listener or musician evaluation.
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URL
https://arxiv.org/abs/2606.07334
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Varifold Moment Invariants for Sustainable and Explainable Contour Feature Extraction
2026-06-05 14:48:04G. Longari, J. -C. Alvarez Paiva, A. B. TumpachAbstract
We introduce Varifold Moments Invariants (VMI) as a unifying framework for many previously introduced Moment Invariants. These invariants are deeply related to other contour features that are invariant under translations and rotations, like Extended Gaussian Image, Elliptic Fourier Descriptors or Shape Distributions. The advantage of the varifold approach to moments consists in being able to combine the geometry of the region, its boundary, and the family of lines tangent to it, in order to create a substantial number of invariant features with high discriminating power and clear geometric meaning. By coupling our VMI feature extraction with the light feature classifiers Random Forest or Multi-Layer-Perceptron, we outperform state-of-the-art approaches based on contours, while decreasing drastically the computational cost to the point of allowing our algorithm to run on light devices. We tested our approach on classification tasks on a large number of widely-used datasets of various types (leaves, objects, cells) and achieved high accuracy with a low number of geometrically interpretable features.
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https://arxiv.org/abs/2606.07333
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OPTIMUS-Prime: Minimal and Sufficient Concept Explanations for Deep Vision Models
2026-06-05 11:44:25Arthur Hoarau, Chenrui Zhu, Vu Linh NguyenAbstract
The growing demand for transparency in automated decision-making has propelled eXplainable Artificial Intelligence (XAI) to the forefront of machine learning research. In computer vision, however, existing explanation methods often prioritize end-user accessibility at the expense of formal guarantees, leaving a critical gap between practical utility and theoretical rigor. In this paper, we address this gap by introducing OPTIMUS, a novel framework for generating concept-based visual explanations for deep classification models. OPTIMUS explanations take the form of visual heatmaps that not only remain interpretable to end users, but are grounded in the well-established theory of prime implicants, providing formal guarantees that have been largely absent from existing saliency-based methods. Specifically, OPTIMUS explanations satisfy two desirable properties: sufficiency, ensuring that the highlighted concepts provably guarantee the classifier's prediction, and minimality, ensuring that no strict subset of those concepts retains this guarantee. Together, these properties yield explanations that are both logically tight and visually coherent. We validate our approach on a visual classification benchmark, demonstrating that OPTIMUS heatmaps naturally and faithfully surface the decision-relevant concepts underlying model predictions.
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URL
https://arxiv.org/abs/2606.07180
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REMEDI: A Benchmark for Retention and Unlearning Evaluation in Multi-label Clinical Disease Inference
2026-06-05 10:51:20Anurag Sharma, Sai Teja Chunchu, Prasenjit Mitra, Sandipan Sikdar, Koustav RudraAbstract
Language models trained for clinical disease inference are trained on patient data, which may include sensitive and private information, and data owners may request the removal of their data from a trained model due to privacy or copyright concerns. However, exactly unlearning patient-specific data is intractable, and retraining with minor data removal is resource-intensive. While there exists several machine unlearning methods that can be used, their utility is generally restricted to non-medical domains. Moreover, the existing benchmarks for evaluating such unlearning methods primarily utilize synthetically curated datasets, which are not truly representative of real-world systems. Hence, the effectiveness of these unlearning methods in the medical domain is largely unclear. To this end, we introduce REMEDI, an extensive benchmark for machine unlearning tailored to multi-label and multiclass clinical disease inference, where label correlations, longitudinal structure, and safety constraints make unlearning particularly challenging. Unlike the existing benchmarks, REMEDI considers: (1) a relevant application domain (medical), (2) comprehensive unlearning setups involving diverse sets of forget instances, (3) challenging unlearning scenarios including multi-label and multi-class classification tasks, and (4) evaluation metrics involving performance both in terms of utility and extent of unlearning achieved. REMEDI is developed using the MIMIC-III clinical database that contains comprehensive clinical data of patients. Experiments with existing unlearning methods indicate that there exists a trade-off between utility and unlearning performance. They are also largely unsuited to multi-label classification tasks. To facilitate reproducibility, we make our benchmark publicly available.
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https://arxiv.org/abs/2606.07141
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GP-Adapter: Gaussian Process CLIP-Adapter for Few-Shot Out-of-Distribution Detection
2026-06-05 09:53:30Taisei Saito, Koretaka Ogata, Takafumi HiroiAbstract
We propose GP-Adapter, a training-free framework that augments CLIP (Contrastive Language-Image Pre-training) with Gaussian Process (GP) uncertainty modeling for few-shot classification and out-of-distribution (OOD) detection. While CLIP achieves strong zero-shot recognition, it yields deterministic similarity scores and offers limited uncertainty information, which is critical under distribution shift and data scarcity. GP-Adapter constructs modality-specific, class-wise one-class GPs on top of frozen CLIP embeddings using an RBF kernel for image features and a linear kernel for text prompts and fuses their predictive statistics to produce a variance-aware confidence score for OOD detection. The method requires no fine-tuning of the CLIP backbone and relies only on a small $K$-shot cache and lightweight hyperparameter selection, with memory cost scaling as $O(CK^2)$ for $C$ classes and $K$ shots. Experiments on ImageNet and multiple OOD benchmarks show that GP-Adapter provides competitive few-shot performance and consistently improves OOD detection when combined with prompt-learning baselines, highlighting the complementarity between GP-based uncertainty modeling and prompt learning. Overall, our results suggest that integrating probabilistic inference with large pre-trained vision-language models can improve reliability in low-data and distribution-shifted settings. Code is available at this https URL
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URL
https://arxiv.org/abs/2606.07102
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MyGardenBird: A Machine-Learning-Ready Bird Sound Dataset for Twelve Common Malaysian Birds
2026-06-05 07:07:22Muhammad Mun'im Ahmad Zabidi, Mohd Yamani Idna Idris, Norisma IdrisAbstract
Bioacoustic datasets from tropical regions remain limited, in part due to the absence of reproducible workflows for aggregating recordings from public archives. We present \textbf{MyGardenBird}, a curated dataset of bird vocalisations representing twelve common species across Peninsular Malaysia and the Indo-Malayan region. Recordings were sourced from Xeno-canto and processed through species-level filtering, manual spectrogram segmentation, and quality control checks. The primary release comprises 7,200 manually validated audio clips (16 kHz, 16-bit PCM mono WAV), balanced at 600 three-second clips per species (6.0 hours total) derived from 1,381 distinct recordings. Metadata includes geospatial coordinates, vocalisation categories, and signal-to-noise ratio (SNR) values (range: 0.83--59.18 dB; mean: 15.80 dB). A supplementary 44.1 kHz version is also provided. To mitigate data leakage, dataset partitions are defined at the source-recording level. Baseline classification experiments using convolutional neural networks on Mel-spectrograms achieved test accuracies of 92--96\%, indicating strong interspecies separability. Limitations include reliance on single-annotator curation; however, validation with BirdNET confirmed label consistency. MyGardenBird is openly available at this https URL under a CC BY-NC-SA 4.0 licence. Complete preprocessing code accompanies the release to support reproducibility and future expansion.
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URL
https://arxiv.org/abs/2606.06975
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When is 3D Worth It? A Resource-Performance Frontier for CNNs and Transformers in Lung CT
2026-06-05 06:24:20Md Enamul Hoq, Sharafat Hossain, Imraul Emmaka, Linda Larson-Prior, Lawrence Tarbox, Jonathan Bona, Donald Johann Jr. and Fred PriorAbstract
Three-dimensional models are widely assumed preferable for volumetric medical imaging, yet their practical value depends on whether performance gains justify added computational cost and complexity. Rather than proposing a new architecture, we study how input dimensionality (2D, 2.5D, 3D) affects model behavior across convolutional neural networks (CNNs) and Vision Transformers (ViTs) under a fixed training protocol. Using a leakage-free NLST cohort (n = 1,977) with supporting LIDC-IDRI data, we find that the 2.5D CNN offers the most favorable discrimination-stability trade-off in our comparison (ROC-AUC 0.682, 95% CI [0.546, 0.799]) with a stable operating point. In contrast, 3D CNNs show threshold instability, and transformers exhibit degenerate predictions, such as all-positive predictions. Confidence intervals are wide and overlapping, so we present these results as a controlled resource-performance frontier and a failure-mode taxonomy rather than as definitive superiority claims. For class-imbalanced lung cancer screening classification, 2D and 2.5D inputs provide a more reliable trade-off between performance, stability, and computational efficiency than full 3D representations.
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https://arxiv.org/abs/2606.06950
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Towards Event-Robust Acoustic Scene Classification
2026-06-05 05:35:03Yiqiang Cai, Bohan Hu, Yu Yang, Pengwei Lu, Shengchen Li, Xi ShaoAbstract
This paper introduces the Event-Shifted Acoustic Scene (ESAS) dataset, a novel benchmark for evaluating the robustness of Acoustic Scene Classification (ASC) systems against unknown sound events. Existing ASC datasets typically contain recordings of clean and consistent audio, while real-world environments often include diverse and unexpected sound events. To bridge this gap, ESAS simulates real-world acoustic variability by injecting foreground sound events into background scenes with the assistance of large language models. In this work, we present the construction methodology, dataset statistics, and evaluation protocols. Furthermore, a comprehensive evaluation of state-of-the-art ASC systems is conducted using the ESAS benchmark. Experimental results reveal that existing ASC models suffer significant performance degradation when facing the event-shift challenge. The introduction of the ESAS dataset aims to drive future research toward event-robust ASC.
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URL
https://arxiv.org/abs/2606.06921
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Lighting-Aware Representation Learning under Controllable Lighting Variation
2026-06-05 04:31:32Lizhen Zhu, Charantej Reddy Pochimireddy, James Z Wang, Brad WybleAbstract
Variations in illumination remain a major challenge for visual representation learning, as they induce substantial appearance changes both across and within environments. While existing approaches typically address this issue through data augmentations that encourage models to become invariant to lighting changes, such strategies do not explicitly model lighting information during learning. Inspired by theories of human vision, we propose a lighting-aware representation learning framework that incorporates illumination variation as an explicit training signal rather than a nuisance factor to be suppressed. Our method extends contrastive learning by introducing an auxiliary objective that captures illumination-dependent variation in rendered scenes, enabling the model to jointly learn representations that preserve semantic consistency while remaining sensitive to lighting-dependent visual structure. We evaluate the proposed model on image classification and object detection tasks across the ImageNet, ExDark, and PASCAL VOC benchmarks. Results demonstrate that the proposed lighting-aware training consistently improves downstream performance over standard contrastive learning baselines, while maintaining the same architecture and training budget. Furthermore, our approach shows promising performance in supervised learning frameworks and under settings involving simpler lighting variation, suggesting broad applicability beyond complex illumination scenarios. These results indicate its potential to enhance model robustness and adaptability in complex visual environments as well as in more conventional image processing tasks.
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URL
https://arxiv.org/abs/2606.06899
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Multi-FRuGaL: Multimodal Flexible Redundancy-aware Decomposed Gated Learning for Cancer Diagnosis and Prognosis
2026-06-05 03:33:43Sanket Kachole, Siddhesh Thakur, Shubham Innani, Sanyukta Adap, Suhang You, Carla Pitarch-Abaigar, Spyridon BakasAbstract
Modern medicine relies on heterogeneous data sources spanning radiology, pathology, text reports, and structured clinical information. However, real-world patient data are frequently incomplete, with missing or sparsely acquired modalities, limiting the effectiveness of standard multimodal fusion approaches. To this end, we propose the Multimodal Flexible Redundancy-aware decomposed GAted Learning (Multi-FRuGaL) framework, a decomposition-aware, adaptive gated intermediate-fusion framework that performs modality-level representation learning under missing data. Multi-FRuGaL integrates per-modality encoders with a signal decomposition layer, an input-conditioned gating network, and an information-aware fusion objective to separate redundant from modality-specific complementary signals, selectively upweighting informative modalities and suppressing redundant or noisy inputs, and remaining well-defined even when multiple modalities are absent. We evaluate Multi-FRuGaL on two multimodal head and neck cancer cohorts: the HANCOCK challenge dataset (N = 763) comprising five modalities and two prognostic endpoints (5-year survival and 2-year recurrence), and the HECKTOR challenge dataset (N = 588) comprising three modalities for human papillomavirus (HPV) status classification. Multi-FRuGaL consistently achieves higher mean performance than the evaluated baselines across multiple tasks, improving AUC from 0.601 to 0.8496 for survival, from 0.672 to 0.8102 for recurrence, and achieving 0.975 AUC for HPV prediction on HECKTOR. For survival analysis, it further achieves a concordance index of 0.6814 for overall survival, 0.7421 for recurrence-free survival, and 0.7143 for progression-free survival on HANCOCK, and 0.7203 for recurrence-free survival on HECKTOR. Qualitative analyses further show that Multi-FRuGaL learns discriminative and robust multimodal representations, even under severe missing-modality conditions.
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https://arxiv.org/abs/2606.06867
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LRMIL: Efficient Low-Resolution Multiple Instance Learning via High-Resolution Knowledge Distillation for Whole Slide Image Classification
2026-06-05 03:21:24Yonghan Shin, Won-Ki JeongAbstract
Multiple instance learning (MIL) has become a standard paradigm for whole slide image (WSI) analysis in digital pathology, as it enables slide-level prediction without dense annotations. Existing MIL methods typically rely on exhaustive extraction and encoding of high-resolution patches. However, this practice suffers from two critical limitations in real-world clinical settings: it struggles to capture global visual cues at lower magnifications, and incurs substantial computational overhead due to the massive number of high-resolution patches per slide. To address these limitations, we propose an efficient low-resolution multiple instance learning (LRMIL) framework that transfers high-resolution knowledge to low-resolution representations. LRMIL adopts a two-stage distillation strategy. First, patch-level cross-resolution distillation aligns low-resolution patch embeddings with high-resolution representations. Second, slide-level knowledge distillation trains a low-resolution student MIL model under both slide-level supervision and teacher guidance. At inference time, LRMIL operates exclusively on low-resolution patches, substantially reducing data preprocessing and computational cost. Extensive experiments on multiple WSI benchmarks demonstrate that LRMIL consistently outperforms state-of-the-art MIL methods while achieving more efficient inference. These results highlight LRMIL as a practical and scalable solution for WSI analysis in clinical pathology.
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https://arxiv.org/abs/2606.06864
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When Better Codebooks Are Not Enough: Predictive Performance and Behavioral Reliability in LLM Political Event Coding
2026-06-04 23:51:14Zixian He, Bharath Raahul Murugesan, Patrick Brandt, Yibo HuAbstract
High accuracy does not necessarily make an LLM a faithful coder. This issue matters because many social-science studies rely on expert-written codebooks to turn text into structured data. We study this problem in political event coding, a challenging source-target relation classification task beyond ordinary sentence-level classification, where models must determine what one actor did to another using detailed coding rules. We test whether expert codebooks become more effective when operationalized into LLM-friendly forms with clearer definitions, examples, retrieved context, and rules for difficult cases. We then evaluate behavioral reliability under controlled changes to label names, codebook order, and label-definition mappings. Clearer codebooks substantially improve classification performance, especially for fine-grained event classification. However, these predictive gains do not fully translate into behavioral reliability. Models may produce valid labels and recover definitions while still failing behavioral reliability tests under controlled codebook changes. These findings suggest that codebook-guided LLM systems should be evaluated not only by accuracy, but also by whether they preserve the coding logic that makes coded outputs meaningful for social-science research.
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URL
https://arxiv.org/abs/2606.06781
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MSAIC-Net: A Multi-Scale Attention and Imbalance-Aware Contrastive Network for ECG-Based Myocardial Substrate Abnormality Detection
2026-06-04 21:08:06Canyu Lei, Fenglin Zhang, Derek Bivona, Cristiane Singulane, Jonathan Pan, Kenneth Bilchick, Amit R. Patel, Jianxin XieAbstract
Myocardial substrate abnormalities, such as myocardial scar and myocardial infarction (MI), are associated with adverse cardiovascular outcomes. Electrocardiography (ECG) provides a low-cost and widely available tool for detecting these abnormalities, but ECG-based detection remains challenging due to heterogeneous lead-dependent manifestations, high-dimensional multi-lead signals, class imbalance, and the limited interpretability of deep learning models. We propose a multi-scale attention-enhanced convolutional network (MSAIC-Net) for ECG-based myocardial substrate abnormality detection. MSAIC-Net employs parallel atrous convolutional branches to extract ECG features across multiple temporal receptive fields. %, enabling the model to capture both local and longer-range temporal patterns. Channel attention is then used to adaptively reweight informative lead-wise and feature-channel representations. To address class imbalance and improve feature separability, we introduce a novel imbalance-aware supervised contrastive learning strategy that encourages samples from the same class to form compact representations while increasing separation between abnormal and normal samples. Lead-wise permutation importance is further incorporated to quantify the contribution of each ECG lead and improve model interpretability. The proposed method was evaluated on two complementary datasets: a low-data institutional cohort from the University of Virginia (UVA) Health System for myocardial scar classification and the large-scale public PTB-XL dataset from PhysioNet for MI identification. Experimental results show that MSAIC-Net outperforms baseline models, with particularly pronounced improvements in the low-data UVA cohort. Overall, the proposed framework provides an effective and interpretable approach for ECG-based detection of myocardial substrate abnormalities.
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https://arxiv.org/abs/2606.06718
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