Deep_Learning
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CoralLite: {mu}CT Reconstruction of Coral Colonies from Individual Corallites
2026-05-14 17:12:59Jess Jones, Leonardo Bertini, Kenneth Johnson, Erica Hendy, Tilo BurghardtAbstract
The life history of an individual coral is archived within the accreting skeleton of the colony. While reef-forming coral colonies (e.g. massive \emph{Porites} sp.) may live for hundreds of years and deposit calcareous structures many metres in height and width, their living tissue is a thin outer surface layer comprised of asexually-dividing polyps that only survive a few years. To understand the rate and timing of polyp division and the consequences for colony skeletal growth, scientists need to track the skeletal corallite deposited around each polyp. Here we propose CoralLite, an annotated {\mu}CT scan dataset of entire calcareous skeletons and an associated, first corallite deep learning reconstruction baseline. CoralLite combines fully quantified volumetric segmentations with cross-slice linking for visualisations of 3D models for each corallite up to colony scale. For segmentation, we propose and evaluate in detail a hybrid V-Trans-UNet architecture applicable to segmenting tiled {\mu}CT virtual slabs of \emph{Porites} sp. colonies. The model is pre-trained on weakly annotated data and topology-aware fine-tuned using fully annotated slice sections with 8k+ manual corallite region annotations. On unseen slices of the same colony, the resulting model reaches 0.94 topological accuracy at mean Dice scores of 0.77 on the same colony and projection axis, and 0.63 mean Dice scores on a different, biologically unrelated specimen. Whilst our experiments are limited in scale and context, our results show for the first time that visual machine learning can effectively support full 3D individual corallite modelling from {\mu}CT scans of coral skeletons alone. For reproducibility and as a baseline for future research we publish our full dataset of 697 {\mu}CT slices, 37 partial or full slice annotations, and all network weights and source code with this paper.
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URL
https://arxiv.org/abs/2605.15093
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Novel Dynamic Batch-Sensitive Adam Optimiser for Vehicular Accident Injury Severity Prediction
2026-05-14 17:06:43Daniel Asare Kyei, Alimatu Saadia-Yussiff, Maame G. Asante-Mensah, Abdul Lateef-Yussiff, Charles Roland Haruna, Derry EmmanuelAbstract
The choice of optimiser is important in deep learning, as it strongly influences model efficiency and speed of convergence. However, many commonly used optimisers encounter difficulties when applied to imbalanced and sequential datasets, limiting their ability to capture patterns of minority classes. In this study, we propose Dynamic Batch-Sensitive Adam (DBS-Adam), an optimiser that dynamically scales the learning rate using a batch difficulty score derived from exponential moving averages of gradient norms and batch loss. DBS-Adam improves training stability and accelerates convergence by increasing updates for difficult batches and reducing them for easier ones. We evaluate DBS-Adam by integrating it with Bi-Directional LSTM networks for accident injury severity prediction, addressing class imbalance through SMOTE-ENN resampling and Focal Loss. Four experimental configurations compare baseline Bi-LSTM models and alternative architectures to assess optimiser impact. Rigorous comparison against state-of-the-art optimisers (AMSGrad, AdamW, AdaBound) across five random seeds demonstrated DBS-Adam's competitive performance with statistically significant precision improvements (p=0.020). Results indicate that DBS-Adam outperforms standard optimisation approaches, achieving 95.22% test accuracy, 96.11% precision, 95.28% recall, 95.39% F1-score, and a test loss of 0.0086. The proposed framework enables effective real-time accident severity classification for targeted emergency response and road safety interventions, demonstrating the value of DBS-Adam for learning from imbalanced sequential data.
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URL
https://arxiv.org/abs/2605.15083
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Predicting Response to Neoadjuvant Chemotherapy in Ovarian Cancer from CT Baseline Using Multi-Loss Deep Learning
2026-05-14 15:53:57Francesco Pastori, Francesca Fati, Marina Rosanu, Luigi De Vitis, Lucia Ribero, Gabriella Schivardi, Giovanni Damiano Aletti, Nicoletta Colombo, Jvan Casarin, Francesco Multinu, Elena De MomiAbstract
Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an advanced stage, with an associated 5-year survival rate of about 30%. Early identification of non-responders to neoadjuvant chemotherapy remains a key unmet need, as it could prevent ineffective therapy and avoid delays in optimal surgical management. This work proposes a non-invasive deep learning framework to predict neoadjuvant chemotherapy response from pre-treatment contrast-enhanced CT by leveraging automatically derived 3D lesion masks. The approach encodes axial slices with a partially fine-tuned pretrained image encoder and aggregates slice-level representations into a volumetric embedding through an attention-based module. Training combines classification loss with supervised contrastive regularization and hard-negative mining to improve separation between ambiguous responders and non-responders. The method was developed on a retrospective single-center cohort from the European Institute of Oncology (Milan, IT), including 280 eligible patients (147 responder, 133 non-responder). On the test cohort, the model achieved a ROC-AUC of 0.73 (95% CI: 0.58-0.86) and an F1-score of 0.70 (95% CI: 0.56-0.82). Overall, these results suggest that the proposed architecture learns clinically relevant predictive patterns and provides a robust foundation for an imaging-based stratification tool.
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URL
https://arxiv.org/abs/2605.14991
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MicroscopyMatching: Towards a Ready-to-use Framework for Microscopy Image Analysis in Diverse Conditions
2026-05-14 15:44:26Xiaofei Hui, Haoxuan Qu, Hossein Rahmani, Shuohong Wang, Jeff W. Lichtman, Jun LiuAbstract
Analyzing microscopy images to extract biological object properties (e.g., their morphological organization, temporal dynamics, and population density) is fundamental to various biomedical research. Yet conducting this manually is costly and time-consuming. Though deep learning-based approaches have been explored to automate this process, the substantial diversity of microscopy analysis settings in practice (including variations of biological object types, sample processing protocols, imaging equipment, and analysis tasks, etc.) often renders them ineffective. As a result, these approaches typically require extensive adaptation for different settings, which, however, can impose burdens that are often practically unsustainable for laboratories, forcing biomedical researchers to still commonly rely on manual analysis, thereby severely bottlenecking the pace of biomedical research progress. This situation has created a pressing and long-standing need for a reliable and broadly applicable microscopy image analysis tool, yet such a tool is still missing. To address this gap, we present the first ready-to-use microscopy image analysis framework, MicroscopyMatching, that can reliably perform key analysis tasks (including segmentation, tracking, and counting) across diverse microscopy analysis settings. From a fundamentally different perspective, MicroscopyMatching reformulates diverse microscopy image analysis tasks as a unified matching problem, effectively handling this problem by exploiting the robust matching capability from pre-trained latent diffusion models.
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URL
https://arxiv.org/abs/2605.14980
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Towards In-Depth Root Cause Localization for Microservices with Multi-Agent Recursion-of-Thought
2026-05-14 14:13:59Lingzhe Zhang, Tong Jia, Kangjin Wang, Chiming Duan, Minghua He, Rongqian Wang, Xi Peng, Meiling Wang, Gong Zhang, Renhai Chen, Ying LiAbstract
As modern microservice systems grow increasingly complex due to dynamic interactions and evolving runtime environments, they experience failures with rising frequency. Ensuring system reliability therefore critically depends on accurate root cause localization (RCL). While numerous traditional machine learning and deep learning approaches have been explored for this task, they often suffer from limited interpretability and poor transferability across deployments. More recently, large language model (LLM)-based methods have been proposed to address these issues. However, existing LLM-based approaches still face two fundamental limitations: context explosion, which dilutes critical evidence and degrades localization accuracy, and serial reasoning structures, which hinder deep causal exploration and impair inference efficiency. In this paper, we conduct a comprehensive study of both how human SREs perform root cause localization in practice and why existing LLM-based methods fall short. Motivated by these findings, we introduce RCLAgent, an in-depth root cause localization framework for microservice systems that realizes multi-agent recursion-of-thought with parallel reasoning. RCLAgent decomposes the diagnostic process along the trace graph by assigning each span to a Dedicated Agent and organizing agents recursively and in parallel according to the graph topology, with the final diagnosis obtained by synthesizing the Root-Level Diagnosis Report and the Global Evidence Graph. Extensive experiments on multiple public benchmarks demonstrate that RCLAgent consistently outperforms state-of-the-art methods in both localization accuracy and inference efficiency.
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URL
https://arxiv.org/abs/2605.14866
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Identifying Culprits Through Deep Deterministic Policy Gradient Deep Learning Investigation
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In the world of AI and advanced technologies investigation aspects identification of a crime or criminal plays a major problem. In this research we focus on a Conventional ways of implicating criminal investigations usually rely on limited data analysis. Finding an optimal and efficient method that will effectively identify criminals from complex datasets and minimise false positives and false negatives is the considered as a challenge. The main novelty approach of this work is based on the deep learning algorithm Deep Deterministic Policy Gradient (DDPG) is presented in this paper. We train the DDPG model with a dataset of crime scene material, witness statements and suspect profiles. The algorithm uses features to maximise the likelihood of identifying the offender while minimising the noise impact and irrelevant data. We show the efficacy of the proposed method, where DDPG identified criminals with an amazing accuracy of 95% than other several existing methods.
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https://arxiv.org/abs/2605.14774
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AI Outperforms Humans in Personalized Image Aesthetics Assessment via LLM-Based Interviews and Semantic Feature Extraction
2026-05-14 12:24:23Yoshia Abe, Tatsuya Daikoku, Yasuo KuniyoshiAbstract
Accurately predicting individual aesthetic evaluation for images is a fundamental challenge for AI. Various deep learning (DL)-based models have been proposed for this task, training on image evaluation data to extract objective low-level features. However, aesthetic preferences are inherently subjective and individual-dependent. Accurate prediction thus requires the extraction of high-level semantic features of images and the active collection of preference information from the target individual. To address this issue, we focus on the utility of Large Language Models (LLMs) pretrained on vast amounts of textual data, and develop an integrated DL-LLM system. The system actively elicits aesthetic preferences through LLM-based semi-structured interviews and predicts aesthetic evaluation by leveraging both low-level and high-level features. In our experiments, we compare the proposed system against conventional systems, human predictors, and the target individual's own re-evaluations after a certain time interval. Our results show that the proposed system outperforms all of them, with particularly strong performance on highly-rated images. Moreover, the prediction error of the proposed system is smaller than within-person variability, while human predictors show the largest error, likely due to the influence of their own aesthetic values. These results suggest that AI may be better positioned than others or one's future self to capture individual aesthetic preferences at a given point. This opens a new question of whether AI could serve as a deeper interpreter of human aesthetic sensibility than humans themselves.
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URL
https://arxiv.org/abs/2605.14761
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Towards Label-Free Single-Cell Phenotyping Using Multi-Task Learning
2026-05-14 11:38:56Saqib Nazir, Ardhendu BeheraAbstract
Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning (DL) framework that jointly performs White Blood Cell (WBC) classification and continuous protein-expression regression from label-free Differential Phase Contrast (DPC) images. Our model employs a Hybrid architecture that fuses convolutional fine-grained texture features with transformer-based global representations through a learnable cross-branch gating module, enabling robust morpho-molecular inference from DPC images. To support downstream interpretability, we further incorporate a Large Language Model (LLM) that generates concise, biologically grounded summaries of the predicted cell states. Experiments on the Berkeley Single Cell Computational Microscopy (BSCCM) and Blood Cells Image benchmarks demonstrate strong performance, achieving a 91.3% WBC classification accuracy and a 0.72 Pearson correlation for CD16 expression regression on BSCCM. These results underscore the promise of label-free single-cell imaging for cost-effective hematological profiling, enabling simultaneous phenotype identification and quantitative biomarker estimation without fluorescent staining. The source code is available at this https URL.
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URL
https://arxiv.org/abs/2605.14717
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Vision-Core Guided Contrastive Learning for Balanced Multi-modal Prognosis Prediction of Stroke
2026-05-14 11:28:57Liren Chen, Lidong Sun, Mingyan Huang, Junzhe Tang, Yinghui Zhu, Guanjie Wang, Yiqing Xia, Ting XiaoAbstract
Deep learning and multi-modal fusion have demonstrated transformative potential in medical diagnosis by integrating diverse data sources. However, accurate prognosis for ischemic stroke remains challenging due to limitations in existing multi-modal approaches. First, current methods are predominantly confined to dual-modal fusion, lacking a framework that effectively integrates the trifecta of medical images, structured clinical data, and unstructured text. Second, they often fail to establish deep bidirectional interactions between modalities; To address these critical gaps, this paper proposes a novel tri-modal fusion model for ischemic stroke prognosis. Our approach first enriches the data representation by employing a Large Language Model (LLM) to automatically generate semi-structured diagnostic text from brain MRIs. This process not only addresses the scarcity of expert annotations but also serves as a regularized semantic enhancement, improving multimodal fusion robustness. Furthermore, we design a core component termed the Vision-Conditioned Dual Alignment Fusion Module (VDAFM), which strategically uses visual features as a conditional prior to guide fine-grained interaction with the generated text. This module achieves a dynamic and profound fusion through a dual semantic alignment loss, effectively mitigating modal heterogeneity. Extensive experiments on a real-world clinical dataset demonstrate that our model achieves state-of-the-art performance.
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https://arxiv.org/abs/2605.14710
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Are Candidate Models Really Needed for Active Learning?
2026-05-14 11:03:29Harshini Mridula Mohan, Maanya Manjunath, Vipul Arya, S. H. Shabbeer Basha, Nitin CheekatlaAbstract
Deep learning has profoundly impacted domains such as computer vision and natural language processing by uncovering complex patterns in vast datasets. However, the reliance on extensive labeled data poses significant challenges, including resource constraints and annotation errors, particularly in training Convolutional Neural Networks (CNNs) and transformers due to a larger number of parameters. Active learning offers a promising solution to reduce labeling burdens by strategically selecting the most informative samples for annotation. However, the current active learning frameworks are time-intensive which select the samples iteratively with the help of initial candidate models. This study investigates the feasibility of using CNNs and transformers with randomly initialized weights, eliminating the need for initial candidate models while achieving results comparable to active learning frameworks that depend on such candidate models. We evaluate three confidence-based sampling strategies: high confidence (HC), low confidence (LC), and a combination of high confidence in the early stages of training and low confidence at later stages of training (HCLC). Among these, mostly LC demonstrated the best performance in our experiments, showcasing its effectiveness as an active learning strategy without the need for candidate models. Further, extensive experiments verify the robustness of the proposed active learning methods. By challenging traditional frameworks, the proposed work introduces a streamlined approach to active learning, advancing efficiency and flexibility across diverse datasets and domains.
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https://arxiv.org/abs/2605.14689
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TERRA-CD: Multi-Temporal Framework for Multi-class and Semantic Change Detection
2026-05-14 10:08:51Omkar Oak, Rukmini Nazre, Rujuta Budke, Suraj SawantAbstract
Urban vegetation monitoring plays a vital role in understanding environmental changes, yet comprehensive datasets for this purpose remain limited. To address this gap, we present the Temporal Remote-sensing Repository for Analyzing Change Detection (TERRA-CD), a benchmark dataset comprising 5,221 Sentinel-2 image pairs from 2019 and 2024, covering 232 cities across the USA and Europe. The dataset features three distinct annotation schemes: 4-class land cover mapping masks, 3-class vegetation change masks, and 13-class semantic change masks capturing all possible land cover transitions. Using various deep learning approaches including Siamese networks, STANet variants, Bi-SRNet, Changemask, Post-Classification Comparison, and HRSCD strategies, we evaluated the dataset's effectiveness for both vegetation Multi-class Change Detection as well as Semantic Change Detection. The proposed dataset and methods are available at this https URL.
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URL
https://arxiv.org/abs/2605.14651
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A plug-and-play generative framework for multi-satellite precipitation estimation
2026-05-14 06:18:53Yunfan Yang, Haofei Sun, Xiuyu Sun, Wei Han, Xiaoze Xu, Xingtao Song, Jun Li, Zhiqiu Gao, Wei Huang, Hao LiAbstract
Reliable precipitation monitoring is essential for disaster risk reduction, water resources management, and agricultural decision-making. Multi-source satellite observations, particularly the combination of geostationary infrared and passive microwave measurements, have become a primary means of precipitation detection. Traditional multi-source satellite precipitation estimation methods remain computationally inefficient, and many deep learning methods lack the flexibility to incorporate new sensors without retraining the full model. Here we introduce PRISMA (Precipitation Inference from Satellite Modalities via generAtive modeling), a plug-and-play latent generative framework for multi-sensor precipitation estimation. PRISMA learns an unconditional precipitation prior from IMERG Final fields and constrains it through independently trained, sensor-specific conditional branches, allowing new observation sources to be incorporated without retraining the generative backbone. Applied to FY-4B AGRI infrared and GPM GMI microwave observations, PRISMA improves Critical Success Index by up to 40.3% and reduces root-mean-square error by 22.6% relative to infrared-only estimation within microwave swaths, while also improving probabilistic skill and maintaining an average inference time of about 37 s. Independent rain-gauge validation across China confirms consistent gains, and typhoon case studies show that microwave conditioning restores eyewall and spiral rainband structures, reducing storm-core mean absolute error by up to 42.3%. PRISMA thus provides an extensible and efficient framework for multi-sensor precipitation estimation.
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URL
https://arxiv.org/abs/2605.14426
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Optimal Pattern Detection Tree for Symbolic Rule-Based Classification
2026-05-14 04:53:18Young-Chae Hong, Yangho ChenAbstract
Pattern discovery in data plays a crucial role across diverse domains, including healthcare, risk assessment, and machinery maintenance. In contrast to black-box deep learning models, symbolic rule discovery emerges as a key data mining task, generating human-interpretable rules that offer both transparency and intuitive explainability. This paper introduces the Optimal Pattern Detection Tree (OPDT), a rule-based machine learning model based on novel mixed-integer programming to discover a single optimal pattern in data through binary classification. To incorporate prior knowledge and compliance requirements, we further introduce the Branching Structure Constraints (BSC) framework, which enables decision makers to encode domain knowledge and constraints directly into the model. This optimization-based approach discovers a hidden underlying pattern in datasets, when it exists, by identifying an optimal rule that maximizes coverage while minimizing the false positive rate due to misclassification. Our computational experiments show that OPDT discovers a pattern with optimality guarantees on moderately sized datasets within reasonable runtime.
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URL
https://arxiv.org/abs/2605.14374
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LoMETab: Beyond Rank-1 Ensembles for Tabular Deep Learning
2026-05-14 04:47:16Changryeol Choi, Hyewon Park, Yujin Kwon, Gowun JeongAbstract
Recent tabular learning benchmarks increasingly show a tight performance cluster rather than a clear hierarchy among leading methods, spanning gradient boosted decision trees, attention-based architectures, and implicit ensembles such as TabM. As benchmark gains plateau, a complementary goal is to understand and control the mechanisms that make simple neural tabular models competitive. We propose LoMETab, a rank-$r$ generalization of multiplicative implicit ensembles. LoMETab lifts the rank-1 BatchEnsemble/TabM modulation to a rank-$r$ identity-residual Hadamard family by parameterizing each member weight as $W_k = W \odot (1 + A_kB_k^\top)$, where $W$ is shared and $(A_k, B_k)$ are member-specific low-rank factors. This exposes two practical diversity-control axes: the adapter rank $r$ and the initialization scale $\sigma_{\mathrm{init}}$, and we prove that for $r \ge 2$ this generalization strictly enlarges BatchEnsemble's hypothesis class. Empirically, we show that this added capacity manifests as measurable predictive diversity after training: on representative classification datasets, LoMETab sustains higher pairwise KL than an additive low-rank ablation, and $(r, \sigma_{\mathrm{init}})$ provides broad control over pairwise KL, varying by up to several orders of magnitude across configurations. The induced diversity is reflected in task-appropriate output-level measures: argmax disagreement for classification and ambiguity for regression, indicating that the control extends beyond pairwise KL to decision- and output-level member variation. Finally, experiments sweeping over adapter rank $r$ and initialization scale $\sigma_{\mathrm{init}}$ reveal that predictive performance is dataset-dependent over the $(r, \sigma_{\mathrm{init}})$ grid, supporting LoMETab as a controllable family of implicit ensembles rather than a fixed rank-1 construction.
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URL
https://arxiv.org/abs/2605.14365
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Detecting overfitting in Neural Networks during long-horizon grokking using Random Matrix Theory
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Training Neural Networks (NNs) without overfitting is difficult; detecting that overfitting is difficult as well. We present a novel Random Matrix Theory method that detects the onset of overfitting in deep learning models without access to train or test data. For each model layer, we randomize each weight matrix element-wise, $\mathbf{W} \to \mathbf{W}^{\mathrm{rand}}$, fit the randomized empirical spectral distribution with a Marchenko-Pastur distribution, and identify large outliers that violate self-averaging. We call these outliers Correlation Traps. During the onset of overfitting, which we call the "anti-grokking" phase in long-horizon grokking, Correlation Traps form and grow in number and scale as test accuracy decreases while train accuracy remains high. Traps may be benign or may harm generalization; we provide an empirical approach to distinguish between them by passing random data through the trained model and evaluating the JS divergence of output logits. Our findings show that anti-grokking is an additional grokking phase with high train accuracy and decreasing test accuracy, structurally distinct from pre-grokking through its Correlation Traps. More broadly, we find that some foundation-scale LLMs exhibit the same Correlation Traps, indicating potentially harmful overfitting.
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https://arxiv.org/abs/2605.12394
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Towards Real-Time Autonomous Navigation: Transformer-Based Catheter Tip Tracking in Fluoroscopy
2026-05-14 01:42:56Harry Robertshaw, Yanghe Hao, Weiyuan Deng, Benjamin Jackson, S. M. Hadi Sadati, Nikola Fischer, Tom Vercauteren, Alejandro Granados, Thomas C. BoothAbstract
Purpose: Mechanical thrombectomy (MT) improves stroke outcomes, but is limited by a lack of local treatment access. Widespread distribution of reinforcement learning (RL)-based robotic systems can be used to alleviate this challenge through autonomous navigation, but current RL methods require live device tip coordinate tracking to function. This paper aims to develop and evaluate a real-time catheter tip tracking pipeline under fluoroscopy, addressing challenges such as low contrast, noise, and device occlusion. Methods: A multi-threaded pipeline was designed, incorporating frame reading, preprocessing, inference, and post-processing. Deep learning segmentation models, including U-Net, U-Net+Transformer, and SegFormer, were trained and benchmarked using two-class and three-class formulations. Post-processing involved two-step component filtering, one-pixel medial skeletonization, and greedy arc-length path following with contour fall-back. Results: On manually-labeled moderate complexity fluoroscopic video data, the two-class SegFormer achieved a mean absolute error of 4.44 mm, outperforming U-Net (4.60 mm), U-Net+Transformer (6.20 mm) and all three-class models (5.19-7.74 mm). On segmentation benchmarks, the system exceeded state-of-the-art CathAction results with improvements of up to +5% in Dice scores for three-segmentation. Conclusion: The results demonstrate that the proposed multi-threaded tracking framework maintains stable performance under challenging imaging conditions, outperforming prior benchmarks, while providing a reliable and efficient foundation for RL-based autonomous MT navigation.
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URL
https://arxiv.org/abs/2605.14253
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Generative Deep Learning for Computational Destaining and Restaining of Unregistered Digital Pathology Images
2026-05-14 01:37:58Aarushi Kulkarni, Alarice Lowe, Pratik ShahAbstract
Conditional generative adversarial networks (cGANs) have enabled high-fidelity computational staining and destaining of hematoxylin and eosin (H&E) in digital pathology whole-slide images (WSI). However, their ability to generalize to out-of-distribution WSI across institutions without retraining remains insufficiently characterized. Previously developed cGAN models trained on 102 registered prostate core biopsy WSIs from Brigham and Women's Hospital were evaluated on 82 spatially unregistered WSIs acquired at Stanford University. To mitigate domain shift without retraining, a preprocessing pipeline consisting of histogram-based stain normalization for H&E-stained WSIs and channel-wise intensity calibration for unstained WSIs was developed. Because image registration was intentionally omitted for real-world deployment conditions, the reported quantitative results are conservative lower bounds reflecting both model performance and limited spatial alignment. Under these conditions, virtual destaining achieved a Pearson correlation coefficient (PCC) of 0.854, structural similarity index measure (SSIM) of 0.699, and peak signal-to-noise ratio (PSNR) of 18.41 dB. H&E restaining from computationally destained outputs outperformed direct staining from ground-truth unstained inputs across all metrics (PCC: 0.798 vs. 0.715; SSIM: 0.756 vs. 0.718; PSNR: 20.08 vs. 18.51 dB), suggesting that preprocessing quality may be more limiting than model capacity. Qualitative pathological review indicated preservation of benign glandular structures while showing that malignant glands were often rendered with vessel-like morphologies. These findings support the feasibility of applying cGAN-based computational H&E staining and destaining generative models to external WSI datasets using preprocessing-based adaptation alone while defining specific morphological targets for future domain adaptation.
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URL
https://arxiv.org/abs/2605.14251
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Bridging the Rural Healthcare Gap: A Cascaded Edge-Cloud Architecture for Automated Retinal Screening
Abstract
Diabetic Retinopathy (DR) is one of the leading causes of preventable blindness, yet rural regions often lack the specialists and infrastructure needed for early detection. Although cloud-based deep learning systems offer high accuracy, they face significant challenges in these settings due to high latency, limited bandwidth, and high data transmission costs. To address these challenges, we propose a two-tier edge-cloud cascade on the public APTOS 2019 Blindness Detection dataset. Tier 1 runs a lightweight MobileNetV3-small model on a local clinic device to perform a binary triage between Referable DR (Classes 2-4) and Non-referable DR (Classes 0-1). Tier 2 runs a RETFoundDINOv2 model in the cloud for ordinal severity grading, but only on the subset of images flagged as referable by Tier 1. On a stratified APTOS test split of 733 images, Tier 1 reaches 98.99% sensitivity and 84.37% specificity at a validation-tuned high-sensitivity threshold. The default cascade forwards 49.52% of test images to Tier 2, reducing cloud calls by 50.48% relative to using a cloud-based model for all images. In the deployed 4-class output space (Class 0-1 / Class 2 / Class 3 / Class 4), the cascade obtains 80.49% accuracy and 0.8167 quadratic weighted kappa; the cloud-only baseline obtains 80.76% accuracy and 0.8184 quadratic weighted kappa. On APTOS, the cascade cuts cloud use by about half with a modest drop in grading performance. Index Terms: Diabetic Retinopathy, Edge-Cloud Cascade, MobileNetV3-small, RETFound-DINOv2, Retinal Screening, tele-ophthalmology
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URL
https://arxiv.org/abs/2605.14108
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Unsupervised learning of acquisition variability in structural connectomes via hybrid latent space modeling
2026-05-13 16:11:49Gaurav Rudravaram, Lianrui Zuo, Karthik Ramadass, Elyssa McMaster, Jongyeon Yoon, Aravind R. Krishnan, Adam M. Saunders, Chenyu Gao, Nancy R. Newlin, Praitayini Kanakaraj, Lori L. Beason Held, Murat Bilgel, Laura A. Barquero, Micah DArchangel, Tin Q. Nguyen, Laurie B. Cutting, Derek Archer, Timothy J. Hohman, Daniel C. Moyer, Bennett A. LandmanAbstract
Acquisition differences across sites, scanners, and protocols in dMRI introduce variability that complicates structural connectome analysis. This motivates deep learning models that can represent high-dimensional connectomes in a low-dimensional space while explicitly separating acquisition-related effects from biological variation. Conventional dimensionality reduction methods model all variance as continuous, so acquisition effects often get absorbed into a continuous latent space. Recent hybrid latent-space models combine discrete and continuous components to address this, but typically require manual capacity tuning to ensure the discrete component captures the intended variability. We introduce an unsupervised framework that removes this manual tuning by architecturally annealing encoder outputs before decoding, allowing the model to adaptively balance discrete and continuous latent variables during training. To evaluate it, we curated a dataset of N=7,416 structural connectomes derived from dMRI, spanning ages 2 to 102 and 13 studies with 25 unique acquisition-parameter combinations. Of these, 5,900 are cognitively unimpaired, 877 have mild cognitive impairment (MCI), and 639 have Alzheimer's disease (AD). We compare against a standard VAE, PCA with k-means clustering, and hybrid models that anneal only through the loss function. Our architectural annealing produces stronger site learning (ARI=0.53, p<0.05) than these baselines. Results show that a hybrid continuous-discrete latent space, with architectural rather than loss-based annealing, provides a useful unsupervised mechanism for capturing acquisition variability in dMRI: by jointly modeling smooth and categorical structure, the Joint-VAE recovers clusters aligned with scanner and protocol differences.
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URL
https://arxiv.org/abs/2605.13933
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Dynamical Predictive Modelling of Cardiovascular Disease Progression Post-Myocardial Infarction via ECG-Trained Artificial Intelligence Model
2026-05-13 14:05:43Riccardo Cavarra, Lupo Lovatelli, Shaheim Ogbomo-Harmitt, Shahid Aziz, Adelaide De Vecchi, Andrew King, Oleg AslanidiAbstract
Myocardial infarction (MI) is a leading cause of death, and its adverse outcomes are urgent to predict. Yet ECG-based prognostic models underperform because deep learning requires large, labelled datasets, which are scarce in medicine. Foundation models can learn from unlabelled ECGs via selfsupervision, but medically relevant training strategies remain underexplored. We propose a pretrained artificial intelligence model that combines patient-specific temporal information using contrastive learning with supervised multitask heads, then fine-tunes on post-MI outcome prediction. The proposed model outperformed a model trained from scratch (0.794 vs 0.608 AUC) showing that clinically structured ECG modelling improves classification in limited data regimes.
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https://arxiv.org/abs/2605.13568
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