Noise poses a widespread challenge in signal processing, particularly when it comes to denoising images. Although convolutional neural networks (CNNs) have exhibited remarkable success in this field, they are predicated upon the belief that noise follows established distributions, which restricts their practicality when dealing with real-world noise. To overcome this limitation, several efforts have been taken to collect noisy image datasets from the real world. Generative methods, employing techniques such as generative adversarial networks (GANs) and normalizing flows (NFs), have emerged as a solution for generating realistic noisy images. Recent works model noise using camera metadata, however requiring metadata even for sampling phase. In contrast, in this work, we aim to estimate the underlying camera settings, enabling us to improve noise modeling and generate diverse noise distributions. To this end, we introduce a new NF framework that allows us to both classify noise based on camera settings and generate various noisy images. Through experimental results, our model demonstrates exceptional noise quality and leads in denoising performance on benchmark datasets.
https://arxiv.org/abs/2608.29038
Time-series data across physical and biological domains are fundamentally driven by complex, non-stationary oscillatory modes. While deep learning models, such as Convolutional Neural Networks (CNNs), Recurrent Neural Networks, and Transformers, have dominated sequential analysis, they remain fundamentally "spectral-blind". By mapping continuous physical waves into unconstrained spatial or discrete token spaces, these architectures suffer from severe spectral entanglement, acting as opaque black boxes that decouple predictive accuracy from physical reality. In this paper, we introduce the Frequency Selective Neural Network (FSNN), pioneering a foundation architecture guaranteeing physical interpretability without sacrificing expressive power of deep learning. FSNN addresses spectral entanglement by explicitly embedding the rigorous mathematics of advanced signal processing into its neural topology. Through a fully differentiable Wiener-like filter bank optimized via complex-domain backpropagation, FSNN autonomously discovers and isolates the precise physical modes of a given task. Extensive evaluations demonstrate that FSNN establishes state-of-the-art predictive performance, achieving $77.0\%$ average accuracy on the standard 10 multivariate UEA datasets and leading across all major metrics on the highly imbalanced PTB-XL clinical ECG benchmark. Crucially, in contrast to yielding abstract feature maps, FSNN converges directly on physically meaningful frequency bands, such as isolating the cardiac QRS complex, providing a highly scalable, interpretable paradigm for robust pattern recognition in complex temporal domains. Our code is available at: this https URL.
https://arxiv.org/abs/2608.29012
The advances in visual information modeling and representation during the last decades are remarkable, mainly supported by Convolutional Neural Networks, Transformer-based, and Foundation Models. Despite this progress, critical challenges regarding the nature of similarity assessment and model transparency have been neglected. A primary concern is the Geometric Gap, where traditional pairwise measures fail to capture the intrinsic geometry of the dataset manifold. Furthermore, the Interpretability Gap persists, as representations often lack alignment with human cognition. Therefore, how to provide interpretability to representations while maintaining low dimensionality and high effectiveness in downstream tasks remains an open challenge. In this paper, we propose a novel unsupervised framework that integrates Manifold Learning strategies with Rank-based Interpretable Graph Embeddings. Our approach effectively bridges these gaps by first characterizing the contextual information of the dataset through manifold analysis and subsequently generating sparse, self-explainable embeddings. The proposed approach employs a flexible formulation, allowing different Manifold Learning and Representation Learning strategies. Extensive experimental evaluation across diverse datasets and features demonstrates that our Context-Aware representations not only provide intrinsic interpretability and dimensionality reduction but also maintain or enhance effectiveness in downstream tasks, specifically in image retrieval and semi-supervised classification using Graph Convolutional Networks (GCNs).
https://arxiv.org/abs/2608.29004
In a data-driven world, efficiently organizing and mapping relationships between objects is crucial. Graphs are powerful tools for modeling these connections, being widely used in social networks, telecommunications, and biology. However, graph-based methods often face high computational costs, particularly in memory and space usage. To address this, graph embedding techniques, also referred to as Network Representation Learning, encode graph information into lower-dimensional representations while preserving structural aspects. Traditional methods, however, lack interpretable dimensions. RaDE (Rank Diffusion Embedding) introduces a new approach using rank-based information, with a key step being the selection of a representative subset of nodes to provide interpretability for its dimensions and improve retrieval tasks. Despite its potential, RaDE's original proposal did not fully explore the effectiveness of representative subset selection across different classes or evaluate embeddings in tasks like classification and clustering. Inspired by RaDE, this work introduces GRaCE (Graph and Rank-based Contextual Embeddings), a fully unsupervised framework that generates interpretable embeddings by leveraging robust rank-based measures for representative subset selection and node embedding. GRaCE surpasses RaDE and Original Features across diverse datasets, including textual and image collections, excelling in retrieval, classification, and clustering tasks, considering state-of-the-art Transformer models as feature descriptors and Graph Convolutional Networks models in classification tasks.
https://arxiv.org/abs/2608.29001
Change detection in Earth observation (EO) is critical for monitoring land surface transformations, yet recent research in the field is constrained by inconsistent evaluation protocols and a narrow focus on predictive accuracy without regard for computational efficiency. To address this, we present a standardized, open-source benchmark for evaluating state-of-the-art (SOTA) deep learning methods for Earth observation change detection. We conduct a comprehensive analysis of ten representative model architectures, ranging from convolutional networks (CNNs) to vision transformers (ViTs), across ten heterogeneous change detection datasets. We rigorously evaluate these models with identical experimental protocols, comparing models trained from scratch against those utilizing pre-trained weights. Furthermore, we evaluate predictive performance alongside computational efficiency, including parameter counts and inference latency. Our findings reveal that well-optimized classical architectures, such as Siamese U-Nets, frequently outperform more complex contemporary models when computational efficiency is factored in, and that pre-training consistently provides a significant performance boost with no additional inference cost. To ensure complete transparency and reproducibility, all experimental resources, including standardized data splits, training scripts, training logs, and model checkpoints are publicly available and adhere to FAIR principles (Findable, Accessible, Interoperable, and Reusable).
https://arxiv.org/abs/2608.28247
The rapid evolution of large language models necessitates robust machine-generated text detection. Existing paradigms typically follow two isolated tracks. Training-free methods rely on global statistical scalars such as perplexity, while training-based methods utilize semantic hidden states. Both approaches exhibit fundamental vulnerabilities in adversarial scenarios. Global scalars act as lossy compressions that obscure local probabilistic burstiness in interleaved texts, whereas pure semantic models overfit to specific fingerprints and remain susceptible to spoofing. To expose these flaws, we introduce MOSAIC, a comprehensive adversarial benchmark comprising 16000 samples across a full-granularity attack spectrum. To address these challenges, we propose NeuroStat, an end-to-end framework bridging the statistical and semantic gap. NeuroStat captures uncompressed token-level probabilistic logits alongside deep semantic hidden states from a single causal language model backbone. We fuse these heterogeneous signals through Macro-State Residual Modulation, which adaptively calibrates local convolutional features using global uncertainty indicators. Orthogonal and contrastive losses further ensure the learning of complementary representations. Extensive experiments demonstrate that NeuroStat maintains exceptional robustness on MOSAIC compared to the severe degradation of state-of-the-art methods, establishing a new standard for adversarial text detection. Code and the MOSAIC benchmark are available at this https URL.
https://arxiv.org/abs/2608.28009
For cooperative perception in the internet of vehicles, this paper proposes a generative adversarial network-based semantic communication framework to address the efficiency and fidelity bottlenecks of traditional communication systems in visual data transmission under limited bandwidth and dynamic channel conditions. At the transmitter, the framework adopts a pyramid attention network to extract semantic label maps and introduces a semantic priority preservation mechanism. It assigns differentiated weights to distinct semantic categories based on driving safety, guiding bit allocation and loss function design. At the receiver, an image reconstruction module integrating a coarse to-fine multi-resolution generator and multi-scale discriminator is designed. Combined with the temporal consistency branch, spatial pyramid pooling and class-aware convolutional layers, it achieves high-fidelity reconstruction of high-quality images from corrupted semantic labels. The model is trained with combined adversarial, feature matching and perceptual losses, effectively improving semantic consistency and visual realism of generated images. Experimental results on the Cityscapes dataset show that the proposed method outperforms existing counterparts in both semantic segmentation accuracy and reconstructed image quality, and maintains stable reconstruction performance under AWGN and Rayleigh channels.
https://arxiv.org/abs/2608.27989
Object classification in event-based computer vision is a task that is attracting considerable research attention. Event-based object classification is a fundamental task in the fields of security and applied computer vision, which typically use synchronous frame-based cameras and computing pipelines for operation. This approach has several practical flaws. The size, weight and power consumption of the device could prohibit deployment at the extreme edge or in covert sensing environments. Besides this, there are security concerns inherent in cloud-based or other off-device computation approaches due to the requirement of sending and receiving potentially sensitive data. Furthermore, this transmission of data introduces latency and requires consistent connectivity to the cloud infrastructure to function. The use of Spiking Neural Networks (SNNs) hosted on neuromorphic devices attempts to solve several issues present in this conventional approach. Research into event-based object classification methods are hindered by the lack of high-quality vision datasets to use. To this end, the ANTShapes simulation tool has been previously proposed to create and label event-based vision datasets. In this paper, four novel datasets of varying difficulties are created using the tool and are benchmarked against existing spiking datasets commonly used for event-based vision research (N-MNIST, CIFAR10-DVS, DVSGesture and POKER-DVS). Classification is performed using a convolutional SNN. This work simultaneously provides four datasets with rich details for future experiments to use and validates the output of the ANTShapes dataset simulation tool as being suitable for its purpose.
https://arxiv.org/abs/2608.27150
This paper proposes a fully differentiable jitter correction method for X-ray phase-contrast micro computed tomography using a deep learning-based image quality metric that estimates and compensates per-projection rigid jitter directly from the acquired projection data, without a pre-scan motion-free reference. The approach builds on a gradient-based auto-focus strategy adapted to parallel-beam geometry. A set of candidate objective functions is benchmarked in a controlled study, and the sensitivity of the visual information fidelity (VIF) metric to the jitter artifact is verified with the target phase-contrast data. To operate without a clean reference, a compact 3D convolutional neural network is trained to predict the VIF score from a single corrupted volume. A spatially selective total variation penalty applied exclusively to the image background is introduced to penalize spurious high-frequency structures that otherwise emerge during optimization. Experiments on biological specimens acquired at different synchrotron beamlines are conducted. Evaluation uses jitter motion applied to simulated and experimentally acquired projection data. The result confirms that the integrated pipeline reliably recovers fine structural detail lost due to jitter, with generalization demonstrated across morphologically distinct samples.
https://arxiv.org/abs/2608.27034
Medical Visual Question Answering (Med-VQA) holds significant promise for clinical decision support, yet faces challenges due to limited annotated data and the high computational demands of existing large vision-language models. We propose MedFG-VQA, a lightweight framework that leverages a memory bank to augment DCT-based low-frequency features and employs graph-enhanced cross-attention for effective visual-textual alignment. Specifically, our approach features two key components: Frequency-Memory Fusion (FMF), which enhances low-frequency features by retrieving from a learnable memory bank built on DCT decomposition, and Graph-Aware Cross-Attention (GACA), which aligns visual-textual features via cross-attention and refines them through graph-convolutional aggregation. To address data scarcity, we construct SynMed-VQA, a large-scale synthetic dataset comprising over 2 million question-answer pairs across 9 imaging modalities and 10 major organs, generated with GPT-4o. Extensive experiments on SynMed-VQA and three other standard biomedical VQA benchmarks demonstrate that MedFG-VQA achieves competitive or superior performance compared to much larger models while maintaining significantly lower computational costs, highlighting its efficiency and potential for clinical deployment.
https://arxiv.org/abs/2608.26848
Automated tea leaf disease classification supports precision agriculture, yet deploying accurate models on edge devices remains challenging under tight compute budgets. Self-supervised vision foundation models such as DINOv2 provide strong features but are too large for field deployment, while lightweight models trained from scratch on small agricultural datasets often underfit. We study cross-architecture knowledge distillation (KD) from a fine-tuned DINOv2 teacher (Vision Transformer) to a compact bidirectional Visual State Space Model (LVSSM) student, an underexplored direction because the architectures use fundamentally different token-mixing mechanisms. We identify and fix two training-stability problems that prevent the from-scratch SSM student from learning on limited data: a single large patch-embedding convolution and a fusion layer that severs the residual path. With a progressive convolutional stem and gated bidirectional selective-scan block, the 4.45M-parameter student trains stably. Across three seeds, temperature-scaled logit distillation raises test accuracy from 92.32+/-2.14% to 95.41+/-1.17% (best single run: 96.20%; macro-F1: 94.45%), a +3.09 percentage-point mean gain. The student uses 5.0 times fewer parameters than the 22M-parameter teacher while retaining 98.3% of its accuracy. Ablations show that intermediate feature-alignment losses reduce accuracy, making simple logit-level KD the strongest configuration. A fair from-scratch comparison shows the gain is specific to students that start below the teacher. We report per-class metrics, confusion matrices, bootstrap confidence intervals, and FLOPs/latency measurements, and discuss limitations including the single-dataset scope and simplified non-official SSM implementation.
https://arxiv.org/abs/2608.26771
This paper introduces a unified mathematical framework for modeling information propagation through convolutional neural networks (CNNs), with the aim of connecting descriptions of physical space and information space. A correspondence is presented linking discrete filter symmetry and the relativistic energy--momentum relation under the widely used nonlinear rectified convolution operation. Specifically, symmetric filter components (e.g. the sum $\Sigma = [1,1]$) operate analogously to rest energy $mc^2$ in preserving the image centre of mass (e.g. isotropic diffusion), whereas antisymmetric components (e.g. the gradient $\nabla = [-1,1]$) operate analogously to the momentum term $pc$ in generally inducing a displacement (e.g. vibration or translation). For typical small discrete filters, this displacement is determined by the ratio of antisymmetric to total filter energy, analogously to how the displacement of a relativistic particle relates to a Lorentz transform with beta parameter $\beta = \frac{v}{c}=\frac{pc}{E}$ equal to the ratio of momentum $pc$ to total energy $E$. Repeated filtering leads to the Gaussian scale-space and emergent scale-invariant features. These constructions share a Laplacian-driven structure with the classical heat (diffusion) equation and, via standard mathematical correspondences, with the Schrödinger equation and aspects of the Friedmann equations, together with emergent Morse topological structure. Demonstrations in 3D images reveal blob-like, scale-invariant Morse critical points in images spanning a wide range of physical scales, including organic sugar molecules and inorganic silicon crystals, human and primate brains in magnetic resonance images (MRI), galaxies and the cosmic microwave background (CMB).
https://arxiv.org/abs/2608.26363
High-resolution precipitation fields are essential for hydrological impact assessment, yet global climate model outputs are too coarse and biased for direct use. AI-based statistical downscaling with diffusion models offers a promising approach, but the mechanism by which large-scale atmospheric predictors condition generation remains largely unexplored. We investigate three conditioning strategies for a denoising diffusion probabilistic model applied to daily precipitation downscaling: channel concatenation of upsampled coarse predictors, cross-attention conditioning with a learned convolutional encoder, and cross-attention conditioning with the frozen encoder of the pretrained Prithvi WxC weather foundation model. All strategies are evaluated against an unconditioned baseline under identical conditions using probabilistic, distributional, spectral, and extreme-event metrics for the Colorado River Basin. Concatenation conditioning achieves the lowest point-wise CRPS and MSE, but tends to produce over-smoothed fields that suppress high-intensity events. In contrast, cross-attention conditioning provides substantially better distributional realism and modest improvements in spectral fidelity. Improvements are greatest for extremes: the Prithvi-WxC conditioned model retains over half of >100mm/day events, although estimates are uncertain due to limited samples. When trained on the full dataset, the learned convolutional model performs similarly to the foundation model-conditioned approach while requiring lower computational resources. However, the Prithvi-WxC-conditioned model achieves comparable performance with only five years of training data. These results indicate that cross-attention conditioning offers advantages over simple concatenation for probabilistic precipitation downscaling, and that pre-trained foundation model representations may offer benefits in data-limited settings.
https://arxiv.org/abs/2608.25858
Accurate 3D segmentation is central to quantitative lesion assessment and anatomy mapping for clinical planning and follow-up. Thin, elongated, and fine anatomical/pathological structures (e.g., vessels) are a particularly challenging case: a one-voxel boundary error can disconnect a branch and change clinically relevant topology. In encoder-decoder networks (e.g., U-Net), repeated downsampling and fixed-grid convolution blur or alias fine structures and weaken orientation cues, so early mistakes propagate across scales. We propose a geometry-guided local operator that steers where features are sampled, rather than deforming convolutional kernels, under a single formulation for both feature refinement (stride 1) and resolution reduction (stride > 1). At each voxel, it predicts a local orientation and bounded step sizes, samples symmetrically along these directions, and transforms paired samples into compact geometric and boundary cues with lightweight mixing; a cross-scale consensus aligns encoder and decoder features at skip connections to reduce geometric mismatch. Replacing all stride 1 and stride 2 operators in a 3D U-Net yields consistent improvements on BraTS, MSD Hepatic Vessel, and TDSC-ABUS, with notably better boundary metrics (e.g., BraTS Dice 86.1 to 88.9, HD95 7.1 to 6.2; TDSC-ABUS HD95 39.1 to 27.8) while reducing parameters from 2.3M to 0.8M. We further demonstrate that the operator can be integrated into other backbones (e.g., nnU-Net, Swin-UNETR, and MedNeXt) without changing their macro-architectures while providing consistent performance gains.
https://arxiv.org/abs/2608.25819
Long-video MLLMs must model temporal change before a limited visual-token budget removes most frame evidence. We introduce LongVU-TTT, which inserts a convolutional Test-Time Training (TTT) resampler with causal fast-weight updates between the vision encoder and the LLM. Its grouped 2D fast weights adapt to each video and contextualize frame features before compression, while a hybrid uniform-and-change-aware selector retains explicit visual evidence for downstream reasoning. Under controlled conditions, TTT-Conv improves over TTT-MLP by up to +2.12 and bidirectional Mamba2 by up to +3.04 on MLVU, and it is stronger than attention- and fixed-state recurrent resamplers across three benchmarks. Analysis shows that the fast weights behave as a temporal aggregation state rather than a reliable long-horizon episodic memory: their benefit attenuates as evidence becomes more distant, motivating explicit frame retention. LongVU-TTT processes up to 512 frames before reducing them to 128 LLM frames and achieves competitive performance across five video understanding benchmarks.
https://arxiv.org/abs/2608.25729
Finger vein verification is a promising biometric modality for secure authentication because vascular patterns are internal, difficult to observe externally, and relatively resistant to presentation attacks. However, reliable verification remains challenging in open-set settings, where test identities are unseen during training and non-enrolled probes must be rejected at inference. This paper presents OpenVeinNet, a finger vein verification framework designed for cross-dataset and open-set evaluation. The proposed model combines Dynamic Snake Convolution with graph-based feature modelling. Dynamic Snake Convolution extracts local curvilinear and tubular vein structures using adaptive sampling, while the graph convolutional backbone models long-range topological relationships between vein regions. To improve the discriminative quality of the embedding space, we introduce a Centroid Angular Hybrid Loss, which jointly encourages intra-class compactness and inter-class angular separation for cosinesimilaritybased verification. Experiments are conducted on five public finger vein datasets: FV-300, MMCBNU, FV-USM, PolyU, and VERA. The method is evaluated using leaveonedatasetout training under both enrolmentbased unknownrejection and fullsubject verification protocols, and is compared with handcrafted and recent deep learning-based baselines. The results show that OpenVeinNet achieves strong cross-dataset generalisation, consistently low equal error rates, and competitive true accept rates at fixed false accept rate operating points. Ablation studies further confirm the individual and combined contributions of adaptive tubular feature extraction, graph-based relational modelling, and the proposed loss function. These findings indicate that explicitly modelling local vein geometry, global vascular relationships, and angularly compact embeddings is effective for openset finger vein verification.
https://arxiv.org/abs/2608.25515
Visual inspection of welded assemblies remains one of the least automated stages in many industrial production processes, still depending largely on the experience of human operators and thus subject to inter-operator variability; the manufacturing of special-purpose machinery cabins, the setting of this study, is one representative case. This work evaluates the feasibility of automatic weld seam segmentation from RGB and polarimetric imagery, comparing controlled laboratory acquisitions with images captured under real, uncontrolled conditions. Convolutional neural network (CNN) architectures and transformer-based architectures are benchmarked under a unified, threshold-independent protocol, training each CNN with three random seeds to separate genuine effects from seed noise. In controlled RGB conditions, CNN models reach a mean mask mAP50 of up to 0.87, but drop to 0.22-0.48 under uncontrolled acquisition, showing that the acquisition setup is a first-order component of the inspection system. Polarimetric imaging with alignment-preserving geometric augmentation localizes previously unseen welds with a mean mask mAP50 up to 0.93: on par with, rather than ahead of, the best controlled-RGB result, but reaching that accuracy on uncontrolled RGB without requiring acquisition control. The clearest architectural finding concerns viewpoint robustness. In-distribution, transformers and CNNs are broadly comparable; but under a test-time viewpoint shift, the transformer models, and RF-DETR in particular, retain high accuracy while every CNN collapses. The gap holds across three seeds and a resolution-matched control, pointing to architecture rather than training resolution. Within the CNN family, capacity brings no reliable in-distribution gain once seed variance is accounted for: small CNNs suffice for fixed viewpoints, transformers for variable ones.
https://arxiv.org/abs/2608.25465
Guided depth super-resolution (GDSR) typically extracts RGB guidance features through convolutional hierarchies, inheriting their fine-to-coarse bias. Thus, low-level spatial cues surface in early layers, leaving the deeper layers to suppress those that do not correspond to true depth boundaries, which risks artifacts and blurred edges. The same fine-to-coarse bias persists in semantics-based methods that consume low-level tokens early and global tokens late. We present WAVE, which introduces a multi-level discrete wavelet transform (ML-DWT) as an explicit and interpretable feature-control mechanism, enabling a coarse-to-fine reconstruction by consuming sub-bands and semantic tokens in reverse of their generation order. WAVE further exploits these sub-bands to treat high- and low-frequency content separately, filtering at its source the misleading RGB color and texture cues that often lead to blurred boundaries and artifacts, offering an intuitive alternative to the suppression learned implicitly by an opaque network. WAVE separates structure and detail reconstruction into dedicated modules that: i) model interactions within and across wavelet sub-bands, depth features, and semantic priors, ii) apply semantic gating to the high-frequency bands, and iii) fuse modalities through an invertible coupling mechanism that prevents collapse onto a single modality. Extensive experiments across multiple benchmarks demonstrate that WAVE matches or outperforms existing methods, with the largest gains at high upsampling factors, where low-resolution depth contains the least structure.
https://arxiv.org/abs/2608.25302
Structural health monitoring (SHM) is essential in modern engineering, providing data for condition-based maintenance, lifecycle assessment, and predictive decision-making. Traditionally, SHM relied on visual inspection to detect defects such as cracks and deformations. Early computer vision (CV) methods, including thresholding, edge detection, and handcrafted features, aimed to automate this process but were highly sensitive to noise, imaging variations, and multiscale defects, limiting their reliability. Recent advances in machine learning, particularly convolutional neural networks (CNNs) and You Only Look Once (YOLO), have improved defect detection accuracy and enabled real-time analysis. However, adoption in SHM remains limited due to technical barriers such as data labeling, model training, and deployment, which typically require programming expertise. To address this gap, we introduce YOLOEZ, an open-source, GUI-based tool for end-to-end YOLO model application. YOLOEZ integrates data labeling, training, and inference into a single interface, enabling high-performance model development without code while supporting reproducible workflows. Evaluation against existing software and classical image processing demonstrates that YOLOEZ not only outperforms traditional methods across most detection metrics, but also lowers adoption barriers present in other modern CV tools. By combining accuracy with accessibility, YOLOEZ facilitates wider use of AI-driven monitoring for predictive maintenance, digital twins, and intelligent structural systems.
https://arxiv.org/abs/2608.25176
Automated malaria diagnosis from stained blood-smear microscopy is dominated by deep convolutional neural networks that are accurate but computationally expensive, poorly interpretable, and rarely validated with patient-level rigor. We present EMFE (Efficient Mathematical Feature Extraction), a five-feature framework for classifying single red-blood-cell images as parasitized or uninfected using Gray World color normalization, adaptive green-channel thresholding, morphological spot detection, and classical machine learning. Using the NIH LHNCBC malaria dataset (27,558 images from 200 patients), we evaluate Random Forest, Histogram Gradient Boosting, and Support Vector Machine classifiers under patient-grouped nested cross-validation (K_outer=20, K_inner=3), ensuring that cells from each patient remain within a single fold. The optimized Random Forest achieves 94.6% pooled out-of-fold accuracy (95% CI [93.6, 95.7]), corroborated by an untouched 40-patient holdout test (94.3%) and a patient-level permutation test (p<0.001, 1,000 permutations). Ablation experiments quantify the contribution of individual features and pipeline stages. Hardware-matched comparisons with retrained DenseNet121, ResNet50, and MobileNetV2 models assess the accuracy-efficiency trade-off. Synthetic perturbations characterize three failure modes, while explainability analysis identifies spot saturation as the dominant discriminative feature. Patient-level aggregation further quantifies sensitivity-specificity trade-offs and false-positive accumulation. These results demonstrate a statistically rigorous, interpretable, and computationally lightweight alternative to deep learning, while explicitly quantifying its limitations.
https://arxiv.org/abs/2608.24793