Represenation_Learning
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Hyperbolic Graph Representation Learning for Differential Diagnosis on Biomedical Knowledge Graphs
2026-09-16 11:11:46Pietro Miotto, Lucia Mellini, Tommaso Marzi, Cesare Alippi, Elena Casiraghi, Alberto Paccanaro, Giorgio Valentini, Mauricio Soto-GomezAbstract
Biomedical knowledge graphs combine ontology-derived hierarchies with transversal associations among heterogeneous entities such as phenotypes, diseases, genes, proteins, and patients. This hybrid structure raises the question of whether hyperbolic embeddings, which naturally capture tree-like organization, remain useful beyond purely hierarchical graphs. We present a preliminary study of hyperbolic graph representation learning for Mendelian-disease differential diagnosis on a patient-integrated biomedical graph. Experiments on isolated ontology subgraphs show that hyperbolic models achieve strong performance in substantially lower dimensions than Euclidean baselines. We then evaluate the models on a link-prediction task that ranks candidate diseases for each patient. Results suggest that hyperbolic embeddings can exploit biomedical hierarchical structure while supporting diagnostic reasoning over heterogeneous patient-level graphs.
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URL
https://arxiv.org/abs/2609.18481
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Mask 2D-3D: Adaptive Dual-Masked Autoencoder Network for Image-to-Point Cloud Registration
2026-09-16 03:47:07Zhixin Cheng, Jiacheng Deng, Xiaotian Yin, Baoqun Yin, Richang Hong, Tianzhu ZhangAbstract
Detection-free methods for image-to-point cloud registration are prone to erroneous correspondences caused by domain and modality discrepancies, limited sensitivity of feature extractors, and the presence of non-overlapping regions. The Masked Autoencoder (MAE) has shown strong performance in visual representation for images and point clouds. It may be helpful to apply this approach to image-to-point cloud registration, a task that requires unified feature extraction and accurate cross-modal correspondences. Standard MAE's random masking may overlook key regions due to limited camera views, reducing registration effectiveness. To address this, we propose the Intermodal Dual-MAE Framework (ID-MAE) with a Similarity-based RL Masking Strategy (SRLM), which adaptively masks informative positions by leveraging cross-modal similarity and reinforcement learning, thus narrowing the modality gap. Our method enhances cross-modal representation learning by enforcing representation consistency during feature extraction, thereby enabling more reliable 2D-3D correspondence estimation. Experiments on RGB-D Scenes v2 and 7-Scenes benchmarks show that our method achieves state-of-the-art performance in image-to-point cloud registration.
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URL
https://arxiv.org/abs/2609.18088
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Hub-Spectral Activation of Latent Multimodal Knowledge
2026-09-15 12:27:42Ying Guo, Haidong Chen, Linrui Xu, Xiaohao Liu, Chuancheng Shi, Canran Xiao, Dan Zhang, Fei Shen, Li Shen, Tat-Seng ChuaAbstract
Multimodal representation learning seeks shared representations for cross-modal retrieval and knowledge transfer. Hub-based binding reduces pairwise supervision costs, but separate hub connections cannot guarantee reliable alignment between modalities without direct joint training. We introduce Hub-Spectral Activation (HSA), a closed-form method for recovering and activating the hub-readable component of latent multimodal knowledge in frozen representations. We formalize this knowledge as source-induced cross-modal dependence and characterize the component determined by the second-order statistics of two trained hub edges. Under a second-order source model, we establish conditions for exact recovery of the complete source-induced relation and bound the dimension of its hub-readable component by the hub covariance rank. HSA composes and standardizes hub-edge statistics, extracts paired spectral directions, and combines reliability-weighted matching evidence with source-gated candidate resolution for bidirectional retrieval and prototype classification. HSA requires no target-pair supervision, gradient optimization, or backbone updates. Across 19 retrieval and 11 prototype-classification relations on ImageBind and LanguageBind, HSA raises mean bidirectional Recall@10 from 18.27% to 31.15% and mean macro Top-1 accuracy from 29.01% to 52.43%, respectively. Controlled analyses further identify valid hub-edge correspondence and leading spectral directions as key sources of retrieval gains, demonstrating the utility of latent multimodal knowledge beyond native similarity scores. Code and models are publicly available at this https URL.
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URL
https://arxiv.org/abs/2609.17094
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Repurposing Unified Topological Signatures for Graph Representation Learning
2026-09-15 12:07:05Sanyam Sanjay Jain, Anshika Krishnatray, Aditya Sharma, Vinti AgarwalAbstract
Message-passing Graph Neural Networks (GNNs) iteratively propagate and aggregate local neighborhood information followed by global readout to learn graph representations. However, their discriminative power is upper-bounded by the Weisfeiler--Lehman (1-WL) graph isomorphism test. This prevents GNNs from distinguishing certain non-isomorphic graphs with identical local neighborhood structures, often leading to similar graph representations. Unified Topological Signatures (UTS) capture compact, multi-scale representation of global graph topology derived from persistent homology. We introduce two complementary UTS signatures: Graph_UTS- a static signature of the input graph topology, and Embedding_UTS- a dynamic signature of the evolving embedding topology. They encode structural information inaccessible to 1-WL-based message-passing GNNs, yet their capabilities are explored solely for post-hoc embedding-space analysis. We integrate UTS into GNN training across three architectural interventions: (i) UTS-Aug: augmenting with standard readout feature that encodes graph's true topology; (ii) UTS-Reg: topological regularizer that constrains representation collapse; (iii) UTS-Pool: topology-guided pooling that retains structurally critical nodes. We further leverage UTS as a layer-wise diagnostic to quantify oversmoothing during GNN training. Theoretically, we show that integrating UTS into GNN optimization strictly extends GNN expressivity beyond the 1-WL hierarchy. Experiments on three graph classification benchmarks show consistent benefits: Graph-UTS, Dual-UTS, and UTS-Pool improve accuracy across all three datasets, Embedding-UTS provides smaller but similarly consistent gains, and UTS-Reg's benefit varies across graph domains. Accuracy improves by up to 5.8% with Graph-UTS augmentation, by up to 1.9% with UTS-Reg, and achieves comparable performance to TOGL with UTS-Pool.
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URL
https://arxiv.org/abs/2609.17061
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SPEAR NeXT Causal Latent Forecasting Across Multiple Horizons for Spectral Temporal Earth Representation Learning
2026-09-15 09:04:10Rajiv Ranjan, Udaiveer Singh, Shashank Tamaskar, Dharmendra SaraswatAbstract
Earth observation is inherently dynamic, yet temporal information in many foundation models is learned through reconstruction, invariance, or retrospective sequence summarization. SPEAR NeXT is introduced as a compact pixel-wise multimodal spectral temporal foundation model in which temporal self supervision is formulated as past only, multi horizon latent Earth state prediction. Instantaneous states are first encoded by the pretrained SPEAR model from optical, radar, and environmental observations into compact 32 dimensional embeddings. Their temporal evolution is then modeled by a causally masked Trans former that predicts multiple future latent states from pre ceding observations. Relative temporal order is represented using Rotary Position Embeddings, while month and year embeddings encode seasonal phase and interannual con text.
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https://arxiv.org/abs/2609.16871
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Hyper-RED: Scalable Event Pre-training via Semantic Hypergraph Distillation
2026-09-15 08:17:37Meisen Wang, Zhiqiang Tian, Wei Bao, Chengjie Wang, Shaoyi Du, Siqi LiAbstract
Event cameras have shown great potential for robust visual perception, yet scaling event representation learning remains challenging due to the scarcity of large-scale annotated event data. Pretrained image models provide scalable semantic supervision, but existing image-to-event methods rely on rigid pixel-wise or token-wise alignment that overlooks modality discrepancies in texture, density, and appearance, potentially causing semantic collapse and limiting transferability. To address this issue, we propose Hyper-RED, a simple, painless, and scalable image-to-event pretraining framework that transfers high-order semantic structures from images to events. Hyper-RED uses hypergraphs to model and align high-order semantic associations among multiple image and event tokens, enabling cross-modal knowledge transfer while accommodating modality-specific differences rather than enforcing rigid one-to-one correspondence. Specifically, given a paired event--image sample, Hyper-RED leverages DINOv3 to extract spatial token representations and constructs image, event, and cross-modal semantic hypergraphs, where each hyperedge connects multiple semantically correlated tokens. We further introduce a hypergraph relational distillation loss that imposes complementary intra- and cross-modal constraints, enabling the event encoder to inherit image-derived semantic organization while preserving local relational consistency and event-specific characteristics. Experiments on three tasks across five event datasets demonstrate consistent scaling from ViT-S to ViT-L and state-of-the-art performance (Fig.1). The code is available at: this https URL.
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URL
https://arxiv.org/abs/2609.16811
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MAETrack: Unleashing the Potential of Pretrained Geometric Priors for 3D Single Object Tracking
2026-09-15 06:21:44Sifan Zhou, Qiwei Wang, Linyue Tan, Ziyu Liu, Ziyu Zhao, Xiaobo LuAbstract
Large-scale pre-training has transformed representation learning in 2D vision, yet its transferability to 3D single object tracking (SOT) remains insufficiently understood. Directly fine-tuning self-supervised 3D encoders, such as masked autoencoders (MAE), often leads to sub-optimal adaptation because the reconstruction objective is not fully aligned with the spatial-temporal matching requirements of tracking. In this paper, we observe that this difficulty can be interpreted as a layer-wise transfer mismatch: shallow layers tend to preserve transferable geometric cues, while deeper layers become increasingly specialized to the reconstruction pretext task and are less suitable for downstream tracking. Based on this observation, we propose MAETrack, a lightweight adaptation framework for transferring pre-training MAE representations to 3D SOT. MAETrack includes Layer-Selective Initialization (LSI), which initializes only the shallow stages of the tracking backbone from pre-trained weights while re-initializing deeper stages, and Geometric Residual Gating (GRG), which reinforces structurally salient regions in the search BEV features before template-search fusion through residual spatial modulation. Extensive experiments on standard 3D SOT benchmarks show that MAETrack consistently improves upon vanilla fine-tuning baselines with limited computational overhead. More broadly, our results suggest that effective transfer from 3D reconstruction pre-training to 3D tracking is not merely a matter of partial fine-tuning, but depends on a tracking-oriented transfer principle that preserves shallow geometry while adapting deeper representations to the downstream objective.
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https://arxiv.org/abs/2609.16695
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FLAT: Resampling Image and Text into 1D Flexible-Length Aligned Transmodal Tokens for Retrieval and Generation
2026-09-15 03:35:59Guangyu Sun, Shlok Kumar Mishra, Wentao Bao, Robert Zhenheng Yang, Xiao Wang, Xiyuan Wang, Yujunrong Ma, Chen Yuan, Max Xiangjun Fan, Jun Xiao, Jianpeng ChengAbstract
Traditional multimodal representation learning and generation are two stages: a contrastive or self-supervised visual encoder is trained first, followed by a separate downstream generative model. This setup bottlenecks generative performance behind frozen embeddings. To bridge this gap, we revisit joint multimodal representation learning and generation to produce linearly interpolatable embeddings that are directly consumable by generative decoders. We present FLAT (Flexible-Length Aligned Transmodal representations), a representation pre-training framework that jointly optimizes a shared multimodal encoder alongside downstream text-to-image (T2I) and image-to-text (I2T) decoders. By combining contrastive alignment with bidirectional cross-modal generative objectives, FLAT ensures its representations function as both discriminative semantic descriptors and generative conditions. Architecturally, FLAT maps visual and textual inputs into a unified continuous 1D sequence space, applying nested dropout over prefix-K tokens to enable dynamic output lengths. A single pre-training stage allows FLAT to perform cross-modal retrieval and generation across variable prefix K, achieving a T2I GenEval score of 71.1. Task-specific fine-tuning aligns model performance with state-of-the-art baselines: 83.1 GenEval on T2I generation; 40.5 BLEU-4 and 138.6 CIDEr on MS-COCO image captioning; and Recall@5 scores of 86.8 (I2T) / 75.8 (T2I) on MS-COCO alongside 98.3 (I2T) / 93.6 (T2I) on Flickr30K. Finally, qualitative evaluations demonstrate that FLAT representations natively support linear interpolation, latent space arithmetic, and zero-shot composed retrieval.
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URL
https://arxiv.org/abs/2609.16591
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Multi-View Molecular Representation Learning with Hierarchical Graphs and Contextualized Fingerprints
2026-09-14 14:07:19Gwang-Hyeon Yun, Jong-Hoon Park, Bing Hu, Helen Chen, Anita Layton, Young-Rae ChoAbstract
Molecular property prediction requires representations that generalize from limited labeled data to structurally novel compounds. Existing molecular pretraining methods often rely on a single view: graph-based approaches model atom-bond topology but provide limited fragment-level supervision, whereas fingerprint descriptors encode chemical patterns but are typically used as fixed auxiliary features. We propose HiFi-Mol, a multi-view framework that separately pretrains a hierarchical graph encoder and a contextualized fingerprint encoder before downstream integration. The graph branch uses fragment-aware masking with multi-resolution supervision to capture substructure-aware representations, while the fingerprint branch tokenizes active entries from seven fingerprint families and applies masked language modeling to learn contextualized embeddings. During fine-tuning, HiFi-Mol combines projected multi-resolution graph features with fingerprint embeddings for downstream prediction. Evaluated on MoleculeNet benchmarks under the scaffold split, HiFi-Mol achieves a 2.77% improvement in average ROC-AUC over the best baseline across eight classification tasks while maintaining competitive performance on three regression tasks. Further analyses reveal that fragment-aware masking improves graph representation quality, and classification results demonstrate dataset-dependent strengths of the individual graph and fingerprint variants, confirming that the two views provide complementary predictive signals.
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URL
https://arxiv.org/abs/2609.15611
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When Correlations Mislead: Confounder-Aware Multi-View Urban Region Representation Learning
2026-09-14 09:53:56Sean Bin Yang, Ying Sun, Zongyi Xu, Tung Kieu, Jilin Hu, Bin Yang, Kristian Torp, Hua Lu, Torben Bach PedersenAbstract
Urban region representation learning commonly combines heterogeneous data sources, such as mobility flows, points of interest, and land-use information, to support tasks including mobility analysis, public safety forecasting, and service demand estimation. Existing multi-view methods typically improve region embeddings by strengthening interactions across views. However, such methods often overlook view-specific regional structures and may propagate correlations induced by shared latent factors, which can reduce the stability of downstream predictions. To overcome this major limitation, we propose CURE, a confounder-aware framework for multi-view urban region representation learning. CURE first encodes each view with its regional graph structure, estimates a shared latent component, and then reduces its projected influence before cross-view interaction. A hierarchical graph-aware fusion module subsequently aggregates the residual view representations using local and global regional contexts Experiments on three real-world cities show that CURE improves predictive performance, remains robust under missing and noisy input views, and provides reliable cross-view integration through shared component separation and context-dependent view weighting.
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URL
https://arxiv.org/abs/2609.15305
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AlignUS: MRI-Guided Ultrasound Representation Learning for ALS Classification from Tongue Images
2026-09-14 09:43:08Kadija Abdel Ghader, Emani Babe, Lorenzo Pettinari, Meya Haroune, Sidaty El HadramyAbstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which early assessment remains challenging, particularly in low-resource settings where MRI is often unavailable. High-resolution ultrasound (HRUS) of the tongue offers a portable and low-cost alternative for evaluating bulbar involvement, but learning reliable diagnostic models is limited by small datasets and the difficulty of extracting robust representations from ultrasound alone. We propose AlignUS, a cross-modal knowledge distillation framework that transfers anatomical knowledge from MRI to a HRUS-based classifier while requiring only HRUS at inference time. The model combines classification loss, supervised contrastive learning, and feature-level distillation to align HRUS representations with MRI embeddings. AlignUS achieves a patient-level balanced accuracy of 0.958, macro-F1 of 0.963, and ROC-AUC of 0.990, aggregated across four patient-level cross-validation folds, with consistent improvements over HRUS baselines and cross-modal alternatives. These results demonstrate that MRI-derived supervision can substantially improve ultrasound-based ALS assessment while preserving low-cost, inference-time independence from MRI.
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URL
https://arxiv.org/abs/2609.15285
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Rethinking Procedural Audio Pre-training: Source Scaling and Objective Adaptation
2026-09-14 05:32:14Jiajun Peng, Fengrui Liu, Xinyu Liu, Feng LiuAbstract
Procedural audio has emerged as a viable source for transferable audio representation learning, but its design principles remain this http URL revisit two questions: how a procedural source should be scaled, and whether training choices developed on natural audio should transfer unchanged to procedural this http URL a controlled source, we separate scale into formula-class coverage C and within-class rendering diversity this http URL with FDSL and AudioMAE show that these two forms of scale provide different benefits and depend on the learning formulation and downstream task. A matched AudioMAE study further shows that procedural audio favors low mask ratios (10%--25%), whereas AudioSet-28K favors 50%--75%. Shared-codebook analysis reveals lower patch diversity and stronger temporal predictability in procedural audio. These results motivate source-aware procedural pre-training, where source scaling and learning configuration are considered this http URL is available at this https URL.
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URL
https://arxiv.org/abs/2609.15067
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Language-Guided Representation Learning for Robust Cross-Sensor Material Recognition
2026-09-13 20:53:14Mashood M. Mohsan, Muhayy Ud Din, Binzhao Xu, Ahmad Abubakar, Irfan HussainAbstract
Robots need touch to manipulate objects safely and reliably, as many properties, such as softness, texture, and contact stability, are hard to infer from vision alone. However, vision-based tactile sensors yield different observations of the same material due to variations in optics, elastomer properties, and illumination, leading to poor generalization when trained on a single or multiple sensors. We propose a language-guided distillation framework for learning sensor-robust tactile representations. Language encodes high-level semantic properties of touch (e.g., rough, soft, slippery) that remain invariant across sensing hardware, providing a natural sensor-agnostic supervisory signal. We construct a 39K-sample touch-language dataset with human-annotated material labels and train a tactile encoder to align sensor-specific tactile images with language embeddings in a shared semantic space. We evaluate our approach for few-shot learning and cross-sensor transfer and benchmark it on six existing tactile datasets. Our method achieves 95% accuracy in the 100-shot setting, improves cross-sensor transfer by an average of 13.3% accuracy, and yields up to 19% accuracy gains across six existing tactile datasets. These results demonstrate that language-guided distillation enables scalable and hardware-agnostic tactile representation learning. Code and dataset are available at this https URL
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URL
https://arxiv.org/abs/2609.14783
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CMA-OT: Hierarchical Expert Supervision for Dance-to-Music Generation
2026-09-11 17:46:15Jinting Wang, Chenxing Li, Dong Yu, Li LiuAbstract
Dance-to-music (D2M) generation aims to synthesize music that is rhythmically and stylistically aligned with dance videos. A key challenge arises from the semantic mismatch between sparse dance cues, such as rhythm and style, and the dense information required for music composition, including structure, instrumentation, and expressive dynamics. Existing methods typically rely on these sparse cues and supervise only the final audio output, resulting in poorly learned music representations and generated music with limited musicality and structural coherence. To address these issues, we propose Curriculum-guided Multi-scale representation Alignment with scale-aware Optimal Transport (CMA-OT), a novel paradigm that leverages an external music expert to provide hierarchical supervision for the generator's latent features, bridging the semantic gap and enhancing representation learning. To effectively incorporate hierarchical supervision, we introduce a curriculum-guided multi-scale learning strategy that progressively transfers musical knowledge from the expert to the music generator, enabling stable and effective representation learning. Moreover, to accommodate the semantic and structural variations across different expert scales and achieve fine-grained alignment under temporal mismatch, we propose a scale-aware optimal transport alignment mechanism, which models soft correspondences between hierarchical expert representations and the generator's latent features. Extensive experiments on two datasets demonstrate that CMA-OT achieves state-of-the-art performance in rhythmic synchronization, perceptual quality, and overall music generation.
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URL
https://arxiv.org/abs/2609.13118
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LM-PCVMNet: Pediatric Cervical Vertebral Maturation Analysis with Deep Fusion of Landmarks and Metadata
2026-09-11 09:33:20Peng Wang, Wanzhen Song, Anli Wang, Xueshuo Xie, Xiaohang Guan, Tao LiAbstract
Cervical vertebral maturation (CVM) assessment plays a pivotal role in orthodontic diagnosis and determining the optimal timing of treatment, especially for pediatric patients. In this paper, we propose LM-PCVMNet, a novel deep learning framework for automatic pediatric CVM staging. Specifically, our method integrates vertebral anatomical landmark information, heatmap-guided feature modulation, and metadata-informed similarity modeling into a unified learning framework. We introduce a heatmap-guided feature modulation module that enhances feature extraction by leveraging landmark-centered heatmaps to highlight morphologically relevant vertebral regions. A vertebral landmark-prompting block is designed to incorporate anatomical geometry into the representation learning process. Furthermore, we develop a learnable metadata supervised contrastive loss that adaptively modulates positive-pair similarity based on metadata similarity, enabling the model to learn more biologically consistent and discriminative features. To facilitate further research in pediatric orthodontic treatment, we additionally release PCVM+. It contains 1800 lateral cephalometric radiographs from real-world patients aged 3-15 years, with expert-annotated CVM stages, 13 vertebral anatomical landmarks, and corresponding metadata. We perform comprehensive experiments on two datasets, and the results show that our method achieves state-of-the-art performance, effectively improving landmark localization and classification accuracy over existing models. Code and dataset will be available at this http URL.
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URL
https://arxiv.org/abs/2609.16033
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STAR: Sparse Tactile Representation Learning in Vision-Tactile-Language-Action Models for Dexterous Manipulation
2026-09-11 07:57:24Xiangcheng Liu, Tianhao Wu, Le Zheng, Yidong Wang, Bowen Jiang, Mingjie Pan, Xinlin Ren, Yi Liu, Jianlan LuoAbstract
Dexterous manipulation requires coordinated multi-finger control and effective tactile feedback, yet learning these capabilities remains challenging due to the lack of large-scale real-world data and the difficulty of extracting effective representations from sparse tactile signals. We build a robot platform and teleoperation system to collect a 200-hour bimanual dexterous manipulation dataset with synchronized visual, tactile, and language annotations, comprising 10,576 trajectories across 65 tasks, 69.5% of which involve dexterous multi-finger manipulation. We further propose STAR, an integrated training recipe for vision-tactile-language-action (VTLA) models that addresses the spatial, temporal, and informational sparsity of tactile signals through visual-tactile joint pre-training, sparse-global tactile token representation, and sparse future tactile prediction. Trained on this dataset, STAR achieves a 61% average success rate across four real-world tasks with 100 post-training trajectories per task, demonstrating dexterous performance under task-specific post-training.
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URL
https://arxiv.org/abs/2609.12549
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PhysioAI: Clinical Knowledge-Guided Semantic Supervision for Skeleton-Based Physiotherapy Action Recognition
2026-09-11 06:41:23Jie Cao, Euijoon Ahn, Anwar Hassan, Jinman KimAbstract
Skeleton-based action recognition can support automated tracking of physiotherapy exercises, particularly in remote rehabilitation settings where continuous in-person supervision is impractical. However, most existing methods are developed for large-scale daily-action benchmarks rather than rehabilitation scenarios. Public rehabilitation exercise datasets are typically small, with only subtle kinematic differences between exercise classes. For participants with motor impairments, exercise execution may also deviate from standard movement patterns in amplitude, speed, and coordination, increasing intra-class variability and making reliable recognition more difficult for skeleton-based models. We propose PhysioAI, a clinical knowledge-guided semantic supervision framework that injects structured physiotherapy knowledge into skeleton representation learning. PhysioAI combines graph-based spatiotemporal modelling of human movement with training-time semantic anchors derived from a structured Clinical Knowledge Dictionary (CKD). The CKD descriptions are encoded using a frozen Contrastive Language-Image Pre-training (CLIP) model and projected into an anchor space, where they provide class-specific semantic targets for skeleton representation learning. The resulting CKD-derived anchors are used only during skeleton-model training; inference requires only skeleton inputs. Under subject-disjoint evaluation, PhysioAI achieves $99.03\pm1.34\%$ on KiMoRe Overall, $94.64\pm7.36\%$ on the Hard-67 stress test, and $87.44\pm7.69\%$ on UI-PRMD Overall. These results exceed the strongest comparator for each endpoint by $0.27$, $2.87$, and $1.33$ percentage points (pp), respectively. These findings demonstrate that structured clinical knowledge can serve as an effective source of training-time supervision for physiotherapy action recognition.
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URL
https://arxiv.org/abs/2609.12491
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Enabling Vision and Cross-Modal Learning for Multimodal Stroke Recurrence Prediction: An Interpretable Two-Step Framework
2026-09-10 13:24:05Christian Gapp, Elias Tappeiner, Martin Welk, Karl Fritscher, Stephanie Mangesius, Constantin Eisenschink, Philipp Deisl, Michael Knoflach, Astrid E. Grams, Elke R. Gizewski, Rainer SchubertAbstract
Multimodal stroke recurrence prediction requires effective integration of heterogeneous clinical and imaging data, yet modality imbalance often causes models to over-rely on dominant modalities and underutilize complementary information. While self-supervised pretraining and selective parameter freezing are commonly employed to improve representation learning and fine-tuning stability, their effect on modality contributions and cross-modal behavior in multimodal medical models remains largely unexplored. In this work, we investigate whether image pretraining on 3D CTA scans reduces modality imbalance and improves cross-modal integration for stroke recurrence prediction, a clinically critical task we recently addressed. To this end, two multimodal neural networks are pretrained in a self-supervised manner and subsequently fine-tuned using two distinct freezing strategies. Their performance and modality utilization are compared against both the baseline model from our previous work and models trained entirely from scratch in this study. Our results demonstrate that self-supervised pretraining enables more effective utilization of the multimodal image-tabular dataset, outperforming both the prior baseline and all non-pretrained models. Notably, the best-performing Vision Transformer based neural network successfully overcomes unimodal collapse. Synergy analysis reveals significant interactions between vision and both gender and CHD, suggesting clinically relevant patterns for stroke recurrence. Overall, our findings demonstrate that self-supervised pretraining and strategic fine-tuning support more balanced modality utilization and enable meaningful cross-modal interactions. Code is publicly available at this https URL.
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URL
https://arxiv.org/abs/2609.22271
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Exploring Diffusion Transformers for Cross-Modal Augmentation in Multimodal Brain State Decoding
2026-09-10 10:20:10Ziwei Wang, Xingyi He, Hongbin Wang, Tianwang Jia, Bohan Fang, Dongrui WuAbstract
Multimodal brain state decoding has largely focused on fusing paired modalities for prediction, but has rarely explored how their correspondence can be further exploited to enrich training data and improve multimodal representation learning. To address this gap, we propose CoMA-DiT, a bidirectional cross-modal Diffusion Transformer for latent augmentation that treats paired modalities as sources of mutual generative supervision rather than merely as inputs to be fused. CoMA-DiT conditions velocity prediction on the paired modality through cross-modal attention and adaptively injects the resulting variation via a reliability-gated residual mechanism. Experiments on multimodal auditory attention decoding and emotion recognition showed that CoMA-DiT consistently outperformed 20 representative baselines, achieving absolute gains of 4.28% and 6.70% in accuracy and macro-F1 over the no-augmentation baseline, respectively. Extensive ablation, sensitivity, visualization, and interpretability analyses further demonstrated its robustness, generalizability, and ability to capture functionally relevant cross-modal interactions. These findings support a broader view of multimodal learning: Paired modalities can serve not only as inputs for fusion but also as supervision sources that augment one another.
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URL
https://arxiv.org/abs/2609.11341
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Representation learning of human cortical folding to reveal long lasting neurodevelopmental signatures
2026-09-10 10:01:52Julien Laval, Robin Guiavarch, Antoine Dufournet, Racim Menasria, Barth\'el\'emy Drabczuk, Cristobal Mendoza, Saeb Tounsi, Chikh Abdelghani Baroud, Merieme Bourenane, Vanessa Troiani, William Snyder, Marisa A Patti, Myl\`ene Moyal, Marion Plaze, Arnaud Cachia, Federica Santacroce, Giorgia Committeri, Claire Cury, Kevin De Matos, Olivier Colliot, Zhong Yi Sun, Clara Fischer, Vincent Frouin, Pietro Gori, Denis Rivi\`ere, Jo\"el Chavas, Jean-Fran\c{c}ois ManginAbstract
The human brain folds in utero, primarily during late gestation. Shortly after birth, cortical folding patterns are established and remain stable thereafter, making them promising early neurodevelopmental markers. Yet it is unclear whether the representations given by current neuroimaging foundation models capture cortical folding variability. Here, we introduce Champollion, a self-supervised learning framework that learns interpretable local representations of cortical folding from structural MRI. Optimized on representative folding-related tasks, Champollion accurately captures known folding patterns across cortical regions and external datasets. In a comprehensive benchmark, it consistently outperforms neuroimaging and general-purpose foundation models. Furthermore, Champollion reveals richer genetic associations than conventional morphometric descriptors and identifies localized folding signatures associated with incomplete hippocampal inversion, prematurity, and maternal smoking. These results establish cortical folding as a rich and largely untapped source of neurodevelopmental information, and Champollion provides a unified framework for discovering, localizing and interpreting long lasting cortical folding signatures.
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URL
https://arxiv.org/abs/2609.05438
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