Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integrating and updating evidence across time and sources to form, revise and justify a patient's problem representation and a defensible plan. This structured narrative review maps three literatures: medical education assessment instruments, clinical LLM benchmarks published from 2023 onwards, and general-domain methods for evaluating long-form generation. We examine six dimensions: problem representation, temporal synthesis, differential and management reasoning, counterfactual reasoning, calibrated uncertainty, and reasoning faithfulness. Preprints are included and flagged. No single instrument covers all six dimensions. Problem representation and differential or management reasoning are reasonably covered, although reliability varies by instrument and setting. TIMER-Eval targets temporal synthesis, and ER-Reason assesses sequential diagnostic belief updating. Dedicated uncertainty and counterfactual evaluations are emerging, but their applicability to longitudinal free-text reasoning remains limited. Factual completeness is well theorised in general-domain evaluation, with early clinical evidence of important omissions. Faithfulness remains the weakest dimension, with one identified clinical causal-ablation study on multiple-choice questions. Existing tools should be combined through binary rubric items, separate completeness and correctness scores, case-specific importance weighting with non-compensable safety caps, temporal order-consistency checks, and chance-corrected reliability reporting. Further design work is needed for calibrated uncertainty, counterfactual reasoning and faithfulness over longitudinal free-text records. This review provides a design rationale, not a validated instrument.
https://arxiv.org/abs/2610.01938
Large Language Models (LLMs) have demonstrated remarkable fluency across many tasks but remain limited by their static, parameter bound knowledge and their susceptibility to hallucinating information. Retrieval Augmented Generation (RAG) addresses these issues by incorporating external retrieval into the generation process, grounding model outputs in verifiable and up to date sources. While prior surveys primarily focus on core RAG architectures and standard pipelines, recent research explores broader challenges and capabilities that extend beyond these foundational designs. This survey provides a consolidated and structured examination of contemporary RAG developments, organizing the field into a four axis taxonomy: improving retrieval efficiency, strengthening robustness and security, supporting user driven and interactive workflows, and enabling multi step or complex reasoning. We formalize key components of the RAG framework and review methods spanning dense and sparse retrieval, fusion strategies, embedding optimizations, and reinforcement learning based retrieval policies, highlighting how these advances influence practical deployment and system design. We also synthesize evaluation practices, domain specific applications, and architectural variants such as Naive, Advanced, and Modular RAG. Finally, we outline persistent challenges related to retrieval quality, reliability, domain adaptation, scalability, and explainability, and identify opportunities for building RAG systems that are more reliable, adaptable, and transparent.
https://arxiv.org/abs/2610.01936
Scuba divers are taught to control their depth to avoid rapid ascents and descents, which could result in serious injuries such as gas embolisms and barotrauma. However, many underwater tasks necessitate lateral control, maintaining distance between subsea structures such as coral reefs, submerged drilling instrumentation, or unexploded ordnance. In this work, we discuss a first-of-its-kind wearable robotic solution providing thruster-actuated directional guidance to a diver, as distinct from prior propulsive-assistance exoskeletons. We introduce ``Robotic Assisted Diver Movement in Confined Spaces'' (RADMCS), a wearable robot that assists divers in maintaining a fixed distance from subsea structures by leveraging perception techniques in monocular depth estimation and force-feedback from submersible thrusters to provide haptic feedback. Its small and compact form factor creates a foundational platform that could be expanded to include more sophisticated control and navigation behaviors. We present results from Institutional Review Board (IRB) in-water studies with eight human scuba diver participants on threshold sensitivity tests in both a closed-water swimming facility and ocean environments; distance-maintaining experiments in a closed-water facility; and form, fit, and function testing in the ocean. We demonstrate that relatively low thrust values (10 percent of maximum) allow robotic direction of a human's movement using the physical sensation of the robot's guidance.
https://arxiv.org/abs/2610.01906
While the literature on blockchain-assisted intrusion detection and prevention systems (IDS/IPS) for Internet of Things (IoT) and Industrial Internet of Things (IIoT) networks is mature, existing systematic reviews suffer from two critical limitations: they overlook the structural shift toward modern Endpoint Detection and Response (EDR) and Extended Detection and Response (XDR) architectures, and they conflate blockchain's distinct functional roles into a single monolithic category. This Systematization of Knowledge (SoK) addresses these gaps by proposing a three-axis taxonomy that classifies proposals by detection-system class (NIDS, HIDS, EDR/XDR), blockchain functional role, and response-automation maturity. Synthesizing research published in high-impact venues between 2019 and 2026, we provide a rigorous gap analysis exposing why a genuine per-endpoint blockchain-anchored response loop remains nearly nonexistent due to latency, deployment, and community mismatches. Furthermore, we evaluate structural, cross-cutting challenges persisting across the literature, including consensus latency on constrained devices, post-quantum cryptographic vulnerability, smart-contract attack surfaces, and the adversarial vulnerability of evolving LLM-based detection engines. Finally, we outline a comprehensive research agenda centered on hybrid on-chain/off-chain orchestration to bridge the gap between decentralized trust and rapid response automation.
https://arxiv.org/abs/2610.01872
Mitotic counting is an important component of tumour grading, diagnosis and prognostic assessment across several tumour types, but manual assessment is time-consuming and subject to inter-pathologist variability. To help address these challenges, we developed MitPro, an AI tool designed to improve consistency and efficiency by directing pathologists towards regions with the highest predicted mitotic activity and highlighting mitotic figures for review, while retaining pathologist control over region selection and the final count. We evaluated its effect on the reproducibility and efficiency of mitotic counting in a retrospective, non-interventional, paired reader study comprising 385 whole-slide images from 3 centres in 3 countries and 7 tumour types using 3 different scanners. 13 pathologists participated, with each slide assessed independently by 3 pathologists without AI assistance and again with AI assistance after a minimum 2 week washout period. Across all slides, AI-assisted counting increased the intraclass correlation coefficient from 0.589 to 0.949. Mean pathologist-level median assessment time decreased from 286.4 to 127.8 seconds, corresponding to an average saving of 151.8 seconds per assessment. Improvements in agreement and efficiency were also observed in supporting analyses using HALO AP and Sectra image management systems and in 2 additional tumour types outside the main study population. AI-assisted assessment was associated with a subtle shift towards higher mitotic counts and scores, consistent with identification of more active mitotic hotspots and fewer missed mitotic figures. The frequency of score change between unassisted and AI-assisted assessment was comparable with inter-pathologist variation during routine counting. These findings support the use of MitPro as an assistive tool for more consistent and efficient mitotic assessment in routine practice.
https://arxiv.org/abs/2610.01813
Artificial intelligence presents an unusually difficult problem for global governance. The technology develops rapidly, crosses borders easily, and is shaped by actors whose resources and capabilities may rival those of states. Yet international responses remain fragmented, unevenly representative, and overwhelmingly non-binding. The challenge is therefore not simply to identify appropriate rules or institutions, but to understand who has the capacity and incentive to create, enforce, and adapt them. This review essay examines these questions through Matthijs Maas's Architectures of Global AI Governance. Maas offers an ambitious framework for thinking about AI governance through the lenses of sociotechnical change, governance disruption, and regime complexity. His account usefully resists both technological determinism and the search for a single institutional blueprint, emphasizing instead the possibilities of a fragmented and evolving governance architecture. The essay argues, however, that institutional design cannot be separated from the distribution of power. Maas frequently invokes what "we" should do about AI, but that collective subject obscures important differences among states, international institutions, and technology companies. States retain formidable powers over markets, infrastructure, strategic inputs, and firms themselves. At the same time, many consequential decisions about frontier AI - what is built, how quickly, with what safeguards, and when it is released - are concentrated within a small number of private companies. The central problem of global AI governance may therefore be less architecture without an architect than an emerging architecture shaped by multiple actors possessing different forms of power, divergent incentives, and no common set of plans.
https://arxiv.org/abs/2610.01716
The emergence of foundation models for molecular property prediction requires a high degree of AI data readiness, including reliable metadata annotation. However, both public repositories and industrial screening databases suffer from missing, inconsistent, or conflated assay annotations. In this work, we quantify the extent of missing annotations in PubChem for the BioAssay Ontology (BAO) assay format and physical detection method fields and investigate whether open-source and proprietary large language models (LLMs) can reliably predict and audit metadata annotations directly from the assay text. In our assessment, we found that the annotation coverage across PubChem's $\sim$2 million bioassays is critically sparse, 36\% lacking an assay format, 89\% a BioAssay type, and >99.9\% any BAO-mapped assay format or detection technology term. This motivates the need for automated test-metadata curation. Using evaluation sets derived from PubChem and ChEMBL, we assess the agreement of seven open-source and proprietary LLMs with existing silver labels. Recall is at least 0.96 for biochemical and cell-based assay formats, with a similar pattern for detection technology, although disagreements increase on under-represented classes. Manual inspection shows that many of these disagreements trace back to inconsistencies between silver sources rather than to LLM error. Moreover, in a qualitative study with a senior industrial curator, LLM-generated evidence prompted the expert to revise some of their own labels, showing LLMs can flag potentially mislabeled assays. Across the study, performance differences between proprietary and open-source models were small. Together, these results suggest LLMs can support the large-scale annotation and auditing of assay metadata, though per-class reliability estimates and targeted human review remain necessary before such labels enter downstream ML pipelines.
https://arxiv.org/abs/2610.01616
Reported improvements from tools and reusable skills in large language model agents refer to different comparisons. This critical narrative review examines what these evaluations estimate and which conclusions their designs support. The review checks the roles of one hundred cited papers and extracts focal evaluation designs in detail from thirty-five studies. Targeted readings of thirty-five additional published or accepted studies broaden coverage of tool creation, memory, interactive benchmarks, reliability, and risk. Designs are characterized by treatment contrast, target population, outcome, budget constraint, summary measure, and identification assumptions. Analytic decompositions and counterexamples show that pairing runs on the same task does not itself identify an invocation effect when evaluation conditions on a trigger within the treated run. Paired gain and regression counts describe discordance under the coupling protocol rather than the share of tasks whose expected outcomes worsen. Total effects of deploying a module answer a different question from efficiency under a common budget. Comparisons across studies distinguish curated skill provision from retriever replacement, task populations from triggered subsets, and preparation costs from marginal usage costs. Publication status and reading depth are recorded. The review provides a methodological synthesis and a reporting checklist to help align claims about tools and skills with the comparisons their evaluation designs support.
https://arxiv.org/abs/2609.33153
Molecular tumor boards integrate genomic findings, clinical context, and therapeutic evidence to support precision oncology. As AI enters this workflow, a key safety challenge is distinguishing truly unsupported recommendations from evidence-supported options that still require oncologist review because of incomplete information, poor ECOG performance status, or other clinical caveats. We introduce OpenMTB-Audit, an open-source benchmark of 500 synthetic non-small cell lung cancer cases spanning five adversarial error categories and four safety labels: Supported, Partially Supported, Unsupported, and Insufficient Information. Across eight large language model configurations, we identify pervasive over-refusal: all LLM configurations failed to retain the Partially Supported label in 83.3-100% of true Partially Supported cases, achieving high aggregate safety scores through label collapse rather than clinically calibrated reasoning. To address this limitation, we developed MTB-AuditAgent, a deterministic seven-module framework separating evidence verification, missing-information detection, safety classification, and abstention. It reduces over-refusal to 6.7% and achieves 91.2% accuracy (95% CI: 88.6-93.6%). A two-oncologist annotation study found disagreement concentrated at the boundary between information sufficiency and treatment optimization, underscoring the need to preserve clinically meaningful distinctions.
https://arxiv.org/abs/2610.01497
Large language models now generate code, documentation, and analyses, and are increasingly used to review such output. We ask when a second review by a different model helps. Building on the author's earlier preprints, which varied context, repetition, and role structure within one model, we test model independence in a controlled experiment: 30 artifacts with 150 planted errors, 10 review conditions, and 900 review sessions with three reviewer models from two developers. In this experiment, (1) a top-tier cross-model reviewer is not significantly different in F1 from same-model review in a fresh session (CCR), which does not establish equivalence; (2) the two find partly different errors (Jaccard 41.2%); and (3) at two review calls, one CCR plus one cross-model review matches more planted errors than two CCR reviews (56.7% vs. 42.7%; Holm-adjusted p=.006), but not significantly more than two reviews by the top-tier cross-model reviewer, so model difference and reviewer capability are not separated. A lightweight cross-model reviewer scores no higher than same-model review. Withholding requirements from the reviewer raises F1 for the two lower tiers but not the top tier, in untested point estimates whose pattern depends on how failed sessions are scored. Before analysis we audited all session records, excluding one baseline run of uncertain provenance and 14 failed calls; results with all sessions are also reported. A partial check on public detector outputs from another benchmark neither replicates nor contradicts the main comparison. Records, artifacts, and scripts are available from the author on request.
https://arxiv.org/abs/2610.01471
We often plan ambitiously yet act habitually and wonder, in retrospect, whether we would have planned differently had we known what we would actually do. Hindsight offers a valuable perspective on past decisions, although we often wish we could have simulated hindsight at the moment of choosing. If a system could generate plausible trajectories from one's personal history, such previews might help people formulate more realistic plans and make better informed decisions. We introduce NextMe-800, an approximately 800-hour first-person dataset from one volunteer over 126 days with 1 Hz images, gaze, and audio, captioned at five hierarchical abstraction levels from atomic actions to major activities. We formulate personalized action anticipation as open-vocabulary K-step sequence prediction and construct NextAct, a 1,500-point benchmark combining NextMe-800 with the multi-person EgoLife dataset. Using an embedding-based soft edit distance as the metric, we evaluate how well different models can anticipate personal behavior across abstraction levels and prediction horizons. NextMe-800 and NextAct provide a months-long resource and evaluation framework for studying how far ahead personal behavior can be anticipated from egocentric observation.
https://arxiv.org/abs/2610.01461
Attributing model behavior to synthetic training data requires knowing what produced each training item before estimating what that item caused. A waveform-label pair does not preserve this knowledge. We propose a generation-provenance substrate in which a synthetic research object binds source specification, generated content, waveform, target, fact requirements, quality signals, review lineage, and immutable manifest identity. Producer and selection mechanism determine evidentiary meaning; storage location and variable name do not. We audit this substrate in a private Japanese care-handoff pipeline. A 113-asset review population contains 1.552 hours of synthetic speech across six scenario families; all items have linked audio, transcripts, candidate notes, and fact checklists, but human evidence is selective and source-specific. Two faithful-only manifests are scenario-seed-disjoint and immutably versioned, while exact upstream attribution remains blocked by floating generator aliases, missing per-clip TTS and code stamps, and an unversioned checking prompt. We argue that generation provenance is necessary but not sufficient for behavior attribution: it defines the candidate causal graph and audit units, whereas contributive attribution still requires frozen training runs and intervention or influence evidence. The paper contributes a compact provenance contract, an audit protocol, and a bounded case study for synthetic-data attribution; controlled research access may be offered, but we do not claim causal training-data attribution, clinical validity, or unrestricted public release.
https://arxiv.org/abs/2610.01378
Model validation estimates the performance of a complete learning procedure on new data. However, an invalid split can produce an optimistic and stable result. This tutorial reviews hold-out validation, train/validation/test designs, repeated random subsampling, k-fold and repeated stratified cross-validation, leave-one-out and leave-p-out schemes, group-aware validation, and nested group cross-validation. General machine-learning principles are linked to EEG epochs, paired-eye OCT images, repeated clinical measurements, and multicenter data. Eight controlled scenarios compare flawed and leakage-safe designs: seven use locked confusion matrices with auditable metrics, and one uses a reproducible repeated-study simulation. The scenarios cover global feature selection, normalization leakage, dependent records, center mixing, repeated test-set use, and estimator instability. Bias, variance, metric aggregation, uncertainty, and computational cost are also examined. A data-size matrix, a decision tree, and reporting checklists are provided. Reproducible MATLAB templates and scikit-learn counterparts are included. The results show that no validation method is universally best. The independent unit must match the intended deployment target. Every data-dependent operation must also exclude the observations used for performance estimation.
https://arxiv.org/abs/2610.01284
The rapid evolution of Intelligent Transportation Systems and Logistics (ITS\&L) has become a cornerstone of the modern social economy, relying heavily on the integration of Data, Artificial Intelligence (AI), and, more specifically, Machine Learning (ML). This paper provides a comprehensive review of Trustworthy Data and Machine Learning Operations (DataOps and MLOps) in the ITS\&L domain, underscoring their importance in improving efficiency, reliability, and decision-making precision within transportation and logistics services. We begin by identifying gaps in current literature, offering clear context for our contribution. Subsequently, we explore the complexities of DataOps and MLOps, discussing their necessity, key components, available tools, practical insights, and case studies relevant to ITS\&L. Additionally, we address the critical issue of Trustworthiness in AI applications, examining methods and tools designed to strengthen confidence in AI systems - especially in real-world ITS\&L scenarios. The paper concludes with a discussion of persisting challenges and future prospects in this rapidly advancing field, aiming to serve as a vital resource for researchers, industry practitioners, and policy makers. Overall, this work not only establishes a foundational understanding of DataOps and MLOps in ITS\&L but also charts a path for further research and innovation in developing more efficient, sustainable, and trustworthy intelligent transportation and logistics systems.
https://arxiv.org/abs/2610.01282
Scientific progress emerges from a longitudinal ecosystem in which researchers, institutions, funding agencies, collaboration networks, and the scientific literature co-evolve. As AI becomes increasingly involved throughout the scientific research cycle, understanding these interconnected and evolving processes becomes increasingly important. We introduce SciUtopia, a persistent, closed-loop LLM-agent simulation framework for studying academic research ecosystems. SciUtopia models interconnected scientific processes such as research-direction choice, collaboration, submission, peer review, resubmission, citation, funding, and researcher attrition, while maintaining evolving states across simulated years. Its configurable institutional mechanisms and information channels provide a controlled testbed for matched counterfactual experiments and targeted interventions. Across 61 simulation worlds, SciUtopia simulates over 40,000 researchers from 8,000 institutions, producing around 400,000 publication decisions and 1.2 million LLM-generated peer reviews. Using these longitudinal simulations, we find that rejection-driven resubmission substantially amplifies reviewer burden beyond population growth alone, cautious exploration balances citation impact with career success and long-term topic diversity, and resource inequality can emerge even without detectable cumulative advantage from narrowly winning early funding. Code is available at this https URL.
https://arxiv.org/abs/2610.01257
As the capabilities and ubiquity of Large Language Models (LLMs) grow, so does their environmental footprint. Despite calls for responsible AI, the machine learning community lacks standardised practices for carbon accounting. Our automated literature review of the 5,285 papers accepted to NeurIPS 2025 reveals that reporting of environmental impact is nearly non-existent. To catalyse a shift toward sustainable AI, we define standardised sustainability metrics for evaluating model training efficiency, accompanied by simple heuristics to estimate the carbon cost of LLM inference. We implement these metrics in carbonbenchmark, a drop-in software solution for tracking and reporting emissions. Finally, to combat the pursuit of marginal accuracy gains at disproportionate environmental costs, we formalise the `Smallest Model that Achieves the Job' (SMAJ), a framework which challenges the field to prioritise computational efficiency and environmental accountability alongside traditional `State-of-the-Art' (SotA) accuracy.
https://arxiv.org/abs/2610.01116
End-to-end research agents can now produce complete scientific papers, yet manuscript claims often diverge from executed experiments. This gap is structural: research state, failure histories, and claim-evidence alignment are not maintained as persistent, verifiable state across long-horizon pipelines. We present YouRA (Your Research Agent), an architecture for stateful, evidence-traceable autonomous research. YouRA preserves research state, execution evidence, and failure history across the research trajectory by integrating three components: a Verification State Architecture (VSA) that tracks hypotheses, gates, and evidence pointers; an Independent Controller that turns state and reflection records into lifecycle, recovery, and debate/review control while separating control from execution; and Stateful Reflection that logs failures as structured lessons and routes recovery through bounded repair, redesign, or reset. On MLR-Bench's predefined ten-task end-to-end subset, YouRA improves over both MLR-Agent and AI Scientist V2 on scalar Overall across all three matched backbones. An automated diagnostic using MLR-Bench's hallucination taxonomy reports intersection/union counts for four fact-based failure types, and data-provenance diagnostic shows more real-data-based outputs. Ablating each of the four components (the VSA, the Independent Controller, MCP tool access, and reflection-guided recovery) supports their separable contributions. Removing either core-state component drops YouRA below the full system. Code: this https URL.
https://arxiv.org/abs/2610.01097
Coding agents can return plausible patches that omit required behavior. These failures are hard to review because long traces and confident summaries often hide what was missed. We ask when a nominally weaker reviewer can reliably decide whether a patch solves its issue. We study 411 execution-labeled traces from three agents and 101 controlled cases. On 154 GPT-5.4 traces, structured but unchecked evidence raises both defect catch and over-rejection. We then provide official execution evidence as an upper-bound diagnostic. After choosing and freezing one of two formats per reviewer, five of six reviewers improve both rates on 122 held-out traces; two classify every trace correctly. Reviewer size is not a consistent predictor of quality. Because official tests are unavailable in deployment, we also evaluate a frozen cascade with patch-caused static errors and generated tests that first fail on the unpatched repository. On 121 scored held-out GPT-5.4 traces and 59 Gemini traces, its coverage is 0.89 and 0.86, risk is 0.33 and 0.26, catch is 0.76 and 0.80, and over-rejection is 0.66 and 0.67. Most false rejections occur when unresolved cases reach the reviewer. Official execution evidence shows the potential of weak review when decisive checks are available. Producing equally reliable checks without official tests remains the main bottleneck.
https://arxiv.org/abs/2610.01023
LLM agents increasingly run policy-bound enterprise workflows, where they must apply rules consistently and stay auditable. Deploying such an agent is the start of its long-term maintenance cycle: it must adapt to a stream of operational signals, yet reliably turning these sparse, unlabeled signals into reusable skill revisions is hard, and a careless update can trade one task category's accuracy for the overall gain, revive a resolved failure, or land at an undeployable cost. We present ESCROW, a post-deployment maintenance framework that updates an agent's external, reviewable skills under a Strict Update Boundary: the LLM proposes candidate revisions, but only an empirically evaluated version is deployed. It combines distributed diagnosis with consensus, a per-category non-regression guard, cross-cycle anti-regression, and accuracy--cost Pareto search, emitting a versioned, auditable diff per change. In real production on our internal financial document-auditing system, it attains the strongest evaluated accuracy--cost trade-off among baselines, with a transfer probe on public $\tau$-bench.
https://arxiv.org/abs/2608.01772
Autonomous driving is a cornerstone technology for the future of intelligent transportation, where end-to-end learning has emerged as a transformative paradigm that directly maps multimodal sensory inputs to driving actions through unified differentiable models. While offering advantages, the effectiveness of end-to-end autonomous driving (E2E-AD) is ultimately determined by the quality of its training ecosystem. This paper provides a comprehensive review of training methods and ecosystem for E2E-AD. We introduce a Data-Strategy-Platform taxonomy that conceptualizes training as an interdependent system. The data layer defines what can be learned, the strategy layer governs how learning aligns with driving objectives, and the platform layer supports scalability and continuous evolution. Within this framework, we survey recent advances across data-centric pipelines, learning paradigms, and training infrastructures, and analyze their interplay in shaping model performance, robustness, and deployability. Finally, we reflect on current limitations and articulate a forward-looking vision that emphasizes a shift from data quantity to data value, from isolated optimization to foundation-driven generalization, and from static training to integrated training-testing loops, aiming toward robust, scalable, and trustworthy autonomous driving systems. We maintain a continuously updated repository tracking cutting-edge literature and works at \href{this https URL}{Our Project Page}.
https://arxiv.org/abs/2610.00926