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Authoring and Management of Transparent Research Integrity Assessments of Randomised Clinical Trial Publications Using LLM-assisted Tools and Provenance Knowledge Graphs

2026-08-07 13:17:56
Milan Markovic, Goutham Indukuri, Somayajulu Sripada, Colby J. Vorland, Jack Wilkinson, Clare Robertson, Mark Bolland, Andrew Grey, Miriam Brazzelli, Alison Avenell
arXiv_AI
           
Abstract

Systematic reviews of Randomised Controlled Trials (RCTs) are routinely used as evidence for clinical care guidelines. Such evidence has to meet high research integrity standards to prevent low quality or false research outputs influencing the clinical care. However, assessing research integrity of published RCTs is a complex process requiring manual effort, and potentially resulting in diverse opinions of the human assessors. This paper describes INSPECT-AI, an LLM-based interactive tool that assists human reviewers with research integrity assessments of published RCTs based on the community approved INSPECT-SR framework, and the Research Integrity Provenance and Evidence ontology (RIPE-O) for documenting the provenance of the assessment process. In addition, we present the Research Integrity Provenance and Evidence knowledge graph (RIPE-KG), an initial set of 140 expert research integrity assessments of 95 RCT publications generated by INSPECT-AI and described using RIPE-O.

Abstract (translated)

URL

https://arxiv.org/abs/2608.07202

PDF

https://arxiv.org/pdf/2608.07202.pdf

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