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PET Quantification-Preserving Registration for Longitudinal Whole-Body PSMA PET/CT

2026-10-15 07:54:21
Fryderyk K\"ogl, Anna Reithmeir, Daniel M. Lang, Emily Chan, Rickmer Braren, Julia A. Schnabel
arXiv_CV
     
Abstract

We adapt the diffeomorphic coarse-to-fine LapIRN architecture for longitudinal whole-body PSMA PET/CT registration in the Learn2Reg 2026 PSMAReg challenge. The method combines affine pre-registration, multi-modal deformable registration, and test-time instance optimization. We further introduce PET biomarker preservation losses for metabolic tumor volume (MTV) and total lesion glycolysis (TLG), including Jacobian-based constraints, and a per-structure rigidity regularization for skeletal structures. The submitted configuration achieved 81.0% DSC and 6.17 mm HD95, with MTV and TLG errors of 3.3% and 3.3%, respectively, on our evaluation protocol. Code is available at this https URL.

Abstract (translated)

URL

https://arxiv.org/abs/2610.21451

PDF

https://arxiv.org/pdf/2610.21451.pdf

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